Study/Year Design NSAID used Conclusions and recommendations Davis and Ackroyd, 1988 [136 ] Prospective double-blinded study of 100 patients with Colles’ fracture Fluriprophen (i) No effect on Colles’ fracture. Adolphson et al., 1993 [137 ] Randomized double-blinded study on 42 postmenopausal women with colles fracture Piroxicam (i) No decrease of the rate of fracture healing Butcher and Marsh, 1996 [138 ] Retrospective review of 94 patients with tibial fracture Not specified (i) Increase in the length of time to union by of 7.6 weeks (
𝑃
=
0
.
0
0
0
3
) (16.7 weeks versus 24.3 weeks). Wurnig et al., 1999 [139 ] 80 prospective patients receiving indomethacin prophylaxis for THR compared with 82 patients without Indomethacin (i) No effect on prosthetic loosening after cementless hip arthroplasty Giannoudis et al., 2000 [140 ] Retrospective review of 377 patients treated with IM nail Ibuprophen and Diclofenac (i) Increased risk for nonunion in patients receiving NSAIDs Bhandari et al., 2003 [141 ] Retrospective review of 192 tibial shaft fractures Not specified (i) Relative risk of 2.02 (
𝑃
=
0
.
0
3
5
) for patient who take NSAIDs Burd et al., 2003 [142 ] Retrospective review of 282 with acetabular fractures Indomethacin (i) Patients receiving indomethacin had increased risk for developing non-union Sculean et al., 2003 [143 ] Randomized blindied study on 20 patients with deep intrabony defect Rofecoxib (i) No effect on the healing of intrabony periodontal defects Bhattacharyya et al., 2005 [144 ] Retrospective review of 9995 humeral shaft fractures treated nonoperatively Not specified (i) Exposure to nonselective NSAIDs in the period 61–90 days after a humeral shaft fracture was associated with nonunion Meunier et al., 2009 [145 ] Randomized study involving 50 patients undergoing total knee replacement Celecoxib (i) No differences in prosthesis migration, pain scores, range of motion, and subjective outcome were found after 2 years
