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The Scientific World Journal
Volume 2012, Article ID 614263, 10 pages
Clinical Study

Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype

1Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
2Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
3Department of Rehabilitation, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
4Department of Neurology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
5Department of Pediatrics, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
6Research Center for Medical Sciences of The 3rd XiangYa Hospital, and The Center for Scientific Research with Animal Models, Central South University, Hunan, Changsha 410013, China

Received 21 October 2011; Accepted 8 December 2011

Academic Editor: Hans Juergen Gallowitsch

Copyright © 2012 Shi-Yong Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Lennox-Gastaut syndrome (LGS) is a devastating and refractory generalized epilepsy affecting children and adolescents. In this study we report the results of resective surgery in 18 patients with LGS phenotype who underwent single-lobe/lesionectomy or multilobe resection plus multiple subpial transection and/or callosotomy. After surgery, seven patients became completely seizure-free (Engel Class I) and five almost seizure-free (Engel Class II). Additional four had significant seizure control (Engel Class III), and two had no change in seizure frequency (Engel Class IV). Of the 4 patients without any lesion on brain MRI, 2 ended with Engel Class II, 1 with III and the other with IV in Engels’ classification. Mean intelligence quotient (IQ) increased from 56.1 ± 8.1 (mean ± SD) before operation to 67.4 ± 8.2 (mean ± SD) after operation, a significant improvement ( 𝑃 = 0 . 0 0 1 ). Results also indicated that the younger the patient at surgery, or the shorter the interval between onset of seizure and resective operation, the better the intellectual outcome. Our data suggest that resective epilepsy surgery can be successful in patients with LGS phenotype as long as the EEG shows dominance of discharges in one hemisphere and corresponding ipsilateral imaging findings, even with contralateral ictal discharges.