TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells
Figure 4
The ability of cytokine-treated MTHCs to stimulate mixed lymphocyte reaction (MLR). (a) The MLR results with MTHCs cotreated with 200 unit/mL TNF-α and IL-4 or IFN-γ as stimulator () and enriched T cells from C57BL/6 mouse spleen as responders (). Stimulators and responders were set up at different ratios as indicated. (b) The effect of CD40L treatment on MLR: different doses of CD40L were added to MLR with IFN-γ + TNF-α-treated MHTCs as stimulators and enriched C57BL/6 spleen T cells as responders (at the ratio of 3.75). The data were the mean ± SE of three separate experiments.
