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The Scientific World Journal
Volume 2012, Article ID 627607, 8 pages
Research Article

Simultaneous Determination of Parathion, Malathion, Diazinon, and Pirimiphos Methyl in Dried Medicinal Plants Using Solid-Phase Microextraction Fibre Coated with Single-Walled Carbon Nanotubes

1Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
2Department of Drug and Food Control, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
3Physiology & Pharmacology Department, Pasteur Institute of Iran, Tehran 13164, Iran
4Center for Air Pollution Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran 14174, Iran

Received 19 October 2011; Accepted 19 December 2011

Academic Editors: A. Berthod, A. A. El-Sayed, K. Gaudin, K. Kannan, and G. O. Thomas

Copyright Ā© 2012 Reza Ahmadkhaniha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A reliable and sensitive headspace solid-phase microextraction gas chromatography-mass spectrometry method for simultaneous determination of different organophosphorus pesticides in dried medicinal plant samples is described. The analytes were extracted by single-walled carbon nanotubes as a new solid-phase microextraction adsorbent. The developed method showed good performance. For diazinon and pirimiphos methyl calibration, curves were linear ( š‘Ÿ 2 ā‰„ 0 . 9 9 3 ) over the concentration ranges from 1.5 to 300 ng  g āˆ’ 1 , and the limit of detection at signal-to-noise ratio of 3 was 0.3 ng  g āˆ’ 1 . For parathion and malathion, the linear range and limit of detection were 2.5–300 ( š‘Ÿ 2 ā‰„ 0 . 9 9 1 ) and 0.5 ng  g āˆ’ 1 , respectively. In addition, a comparative study between the single-walled carbon nanotubes and a commercial polydimethylsiloxane fibre for the determination of target analytes was carried out. Single-walled carbon nanotubes fibre showed higher extraction capacity, better thermal stability (over 3 5 0 āˆ˜ C), and longer lifespan (over 250 times) than the commercial polydimethylsiloxane fibre. The developed method was successfully applied to determine target organophosphorus pesticides in real samples.