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The Scientific World Journal
Volume 2012, Article ID 634835, 5 pages
http://dx.doi.org/10.1100/2012/634835
Research Article

DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease

1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
2College of Medicine, Chang Gung University, Kaohsiung, Taiwan
3Department of Healthcare Management, Yuanpei University, Hsinchu 30015, Taiwan
4Department of Medical Research and Pediatrics, Show Chwan Memorial Hospital in Chang Bing, Changhua 505, Taiwan
5Department of Nursing, Chang Gung Memorial Hospital, Chiayi, Taiwan
6Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
7Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan

Received 10 November 2011; Accepted 2 January 2012

Academic Editors: A. Asea and E. Ayroldi

Copyright © 2012 Hong-Ren Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. High-dose intravenous immunoglobulin (IVIG) is the most effective therapy for KD to reduce the prevalence of coronary artery lesion (CAL) formation. Recently, the α2, 6 sialylated IgG was reported to interact with a lectin receptor, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 (SIGN-R1) in mice and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) in human, and to trigger an anti-inflammatory cascade. This study was conducted to investigate whether the polymorphism of DC-SIGN (CD209) promoter −336 A/G (rs4804803) is responsible for susceptibility and CAL formation in KD patients using Custom TaqMan SNP Genotyping Assays. A total of 521 subjects (278 KD patients and 243 controls) were investigated to identify an SNP of rs4804803, and they were studied and showed a significant association between the genotypes and allele frequency of rs4804803 in control subjects and KD patients ( 𝑃 = 0 . 0 0 4 under the dominant model). However, the promoter variant of DC-SIGN gene was not associated with the occurrence of IVIG resistance, CAL formation in KD. The G allele of DC-SIGN promoter −336 (rs4804803) is a risk allele in the development of KD.