A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers

Table 13

Effect of piperine on plasma concentration of norfloxacin in rabbits [95].

Time (h)	Norfloxacin (μg/mL)	Norfloxacin + piperine (μg/mL)
0.0	0	0
1.0	10.593 ± 0.26	14.125 ± 0.27
2.0	7.079 ± 0.26	17.783 ± 0.32
3.0	5.623 ± 0.32	14.963 ± 0.27
4.0	5.011 ± 0.38	11.885 ± 0.32
5.0	4.732 ± 0.26	10.592 ± 0.37
6.0	3.981 ± 0.26	8.414 ± 0.25
7.0	3.548 ± 0.21	8.414 ± 0.26
8.0	3.349 ± 0.26	7.079 ± 0.26
9.0	3.162 ± 0.27	7.079 ± 0.27
10.0	2.512 ± 0.27	5.623 ± 0.27
11.0	2.238 ± 0.26	5.011 ± 0.27
12.0	1.778 ± 0.26	4.467 ± 0.27

n = 6, mean ± SD, P < 0.