A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers

Table 17

Comparison of pharmacokinetic parameters of gatifloxacin- and gatifloxacin + piperine-treated layer birds after single oral administration (10 mg/kg) [101].

Pharmacokinetic	Gatifloxacin	Gatifloxacin + piperine
parameters
𝐶max (μg/mL)	1.74 ± 0.023	2.14 ± 0.019*
AUC (μg·h/mL)	15.25 ± 0.219	17.54 ± 0.204*
𝑡max (h)	2 ± 0.0	2 ± 0.0
𝑡1/2 (h)	3.74 ± 0.073	4.03 ± 0.097*
𝑉𝑑 (L/kg)	3.54 ± 0.038	3.33 ± 0.083*
𝐹 (%)	74.52 ± 1.021	85.74 ± 0.956*

n = 6, mean ± SE; **Highly significant at P < 0.01, *Significant at P < 0.05.