A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers

Table 19

Comparison of pharmacokinetic parameters of losartan potassium- and losartan potassium + piperine-treated male New Zealand white rats after single oral administration (100 mg/kg) [105].

Pharmacokinetic	Losartan potassium	Losartan potassium
parameters		+ piperine
𝐶max (pg/mL)	32,461 ± 1436	48,399 ± 6060
AUC0–24 (pg·h/mL)	1,10,441 ± 5280	1,69,924 ± 14,343
𝑡max (h)	1.0 ± 0.0	1.0 ± 0.0
𝐾el (mL/h)	0.295 ± 0.002	0.283 ± 0.022
𝑡1/2 (h)	2.34 ± 0.01	2.44 ± 0.195
𝑉𝑑 (L)	3.0 ± 0.15	2.0 ± 0.25

n = 3, mean ± SE.