Review Article
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Table 28
Pharmacokinetic parameters of paeoniflorin (150 mg/kg) and in combination with sinomenine (90 mg/kg) after oral administration in rats [
201].
| Parameters | Paeoniflorin | Sinomenine + paeoniflorin |
| AUC0–∞ (μg·h/mL) | 124.62 ± 36.91 | 1540.43 ± 548.96** | (μg/mL) | 1.26 ± 0.23 | 6.03 ± 2.45* | (min) | 45.00 ± 5.00 | 77.30 ± 17.50* | (min) | 19.58 ± 9.01 | 53.78 ± 22.17*** | (mL/kg/min) | 1301.83 ± 429.03 | 110.44 ± 45.61* | (mL/kg) | 102044.14 ± 46608.43 | 16064.25 ± 17189.33*** | MRT (min) | 133.12 ± 38.63 | 224.07 ± 26.62* |
|
|
n = 6, mean ± SD; *P < 0.01, **P < 0.001, ***P < 0.05.
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