A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers

Table 30

Pharmacokinetic parameters of fexofenadine (60 mg) and in combination quercetin (500) mg after a single-dose administration [50].

Parameters	Fexofenadine	Fexofenadine + quercetin
AUC0–∞ (ng·h/mL)	2,075.5 ± 461.7	3,227.1 ± 665.9
𝐶max (ng/mL)	295.3 ± 135.4	480.3 ± 163.7
𝑡max (h)	2.0 (0.5–5)	2 (1.5–3)
𝐾el (/h)	0.16 ± 0.02	0.16 ± 0.05
𝑡1/2 (h)	4.5 ± 0.8	4.7 ± 1.5
Cl𝑅 (L/h)	4.72 ± 1.13	4.29 ± 1.40

Data are expressed as mean ± SD except for 𝑡_max, which is expressed as median (range).