Review Article
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Table 31
Pharmacokinetic parameters of etoposide (9 mg/kg) and in combination with quercetin after oral administration in rats [
220].
| Parameters | Etoposide control | Quercetin + etoposide | 1 mg/kg | 5 mg/kg | 15 mg/kg |
| AUC (ng·h/mL) | 1226 ± 154 | 1419 ± 222 | 1753 ± 315* | 1878 ± 364** | (ng/mL) | 484 ± 74.7 | 455 ± 80.5 | 586 ± 89.5* | 673 ± 93.3* | (mL/kg/h) | 8265 ± 1566 | 7178 ± 1391 | 5980 ± 1292* | 5481 ± 1167* | (h) | 0.500 ± 0.158 | 0.667 ± 0.129 | 0.693 ± 0.154 | 0.708 ± 0.188 | (/h) | 0.255 ± 0.031 | 0.230 ± 0.027 | 0.225 ± 0.025 | 0.221 ± 0.018 | (h) | 2.75 ± 0.32 | 3.05 ± 0.37 | 3.11 ± 0.39 | 3.16 ± 0.41 | AB (%) | 8.87 ± 1.33 | 10.3 ± 1.55 | 12.7 ± 1.96* | 13.6 ± 2.24** | RB (%) | 100 | 116 | 143 | 153 |
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n = 6, mean ± SD; *P < 0.05, **P < 0.01 compared to control.
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