Review Article
A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers
Table 33
Pharmacokinetic parameters of verapamil (9 mg/kg) and in combination with naringin pretreated rabbits after oral administration [
222].
| | Parameters | Verapamil control | Naringin pretreatment | | 1.5 mg/kg | 7.5 mg/kg | 15 mg/kg |
| | AUC (ng·h/mL) | 291 ± 75.7 | 370 ± 96.1* | 445 ± 1025** | 494 ± 142** | | (ng/mL) | 55.3 ± 14.4 | 66.5 ± 17.3 | 86.9 ± 53.3** | 92.6 ± 54.5** | | (h) | 0.25 ± 0.07 | 0.25 ± 0.08 | 0.25 ± 0.06 | 0.25 ± 0.08 | | (/h) | 3.8 ± 0.99 | 5.1 ± 1.30 | 6.1 ± 1.59* | 6.8 ± 1.72* | | (h) | 12.0 ± 3.12 | 13.4 ± 3.46 | 13.6 ± 3.51 | 13.9 ± 3.61 | | AB (%) | 8.8 ± 2.3 | 11.2 ± 2.8* | 13.5 ± 3.2** | 15.0 ± 3.4** | | RB (%) | 100 | 126 | 153 | 169 |
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n = 6, mean ± SD; *P < 0.05, **P < 0.01, significant difference compared to control.
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