A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers

Table 5

Comparative pharmacokinetic parameters after oral supplementation of curcumin and curcumin + piperine in human volunteers [79].

Parameters	Curcumin	Curcumin (2 g/kg) + piperine
	(2 g/kg)	(20 mg/kg)
𝐶max (μg/mL)	1.35±0.23	1.80±0.16
𝑡max (h)	0.83±0.05	1.29±0.23
𝑡1/2 (h)	1.70±0.58	1.05±0.18
AUC (μg·h/mL)	2.36±0.28	3.64±0.31
Cl𝐵 (L/h)	713±12	495.90±193.90