A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers

Table 9

Comparative pharmacokinetic parameters of oxytetracycline administered orally (10 mg/kg) in control and P. longum treated birds [91].

Parameters	Control OTC	Treated OTC + piperine
β (/h)	0.147 ± 0.011	0.112 ± 0.006*
𝑡1/2𝛽 (h)	4.934 ± 0.422	6.370 ± 0.438**
AUC (μg·h/mL)	5.055 ± 0.689	6.417 ± 0.317*
AUMC (μg·h^2/mL)	43.62 ± 11.15	63.58 ± 7.042*
MRT (h)	7.98 ± 0.744	9.77 ± 0.644**
𝑡𝑑 (h)	16.38 ± 1.4	21.142 ± 1.453**
Cl𝐵 (mL/kg/h)	184.63 ± 7.7	145.97 ± 14.42**

n = 8, mean ± SE; *P < 0.01, **P < 0.05.