Research Article
Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement
Table 1
Summary of saliva proteins with expression change during orthodontic treatment.
| Spot no. | Protein name | Accession number (UniProt) | MW (kDa)/pI | Peptides matched/% coverage (Protein score) | Expression change | Theoretical | Experimental |
| 1 | Protein S100-A9 (S100 calcium-binding protein A9) (Calgranulin-B) | P06702 | 13.2/5.71 | 14.5/5.47 | 4/24% (121) | Downregulated at day 14 | 2 | Serum albumin precursor | P02768 | 69.3/5.92 | 14.8/7.00 | 8/11% (105) | Downregulated at day 14 | 3 | Immunoglobulin J chain | P01591 | 15.5/4.62 | 34.0/3.86 | 10/30% (220) | Downregulated at day 14 | 4 | Immunoglobulin J chain | P01591 | 15.5/4.62 | 36.4/3.40 | 6/27% (198) | Downregulated at day 14 | 5 | Ig alpha-1 chain C region | P01876 | 37.6/6.08 | 44.76/6.91 | 9/20% (260) | Downregulated at day 14 | 6 | Cysteine-rich secretory protein 3 precursor (CRISP-3) | P54108 | 27.6/8.09 | 43.25/8.90 | 2/6% (94) | Present only at day 14 | 7 | Hemoglobin subunit beta (Hemoglobin beta chain) (Beta-globin) | P68871 | 15.9/6.75 | 14.83/9.50 | 6/27% (158) | Present only at day 0 | 8 | 14-3-3 protein σ (Stratifin) (Epithelial cell marker protein 1) | P31947 | 27.7/4.68 | 44.76/4.20 | 5/22% (147) | Present only at day 0 |
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These are proteins that show statistically significant change () between day 0 and day 14 of orthodontic treatment.
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