Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

Figure 2

Proposed pathogenesis during progression of chronic lung damage in feedlot cattle and its relationship with BO/OP and COPD. Viral infection provides the original insult. Mycoplasma bovis has a prominent role in the progression of chronic lung damage. Treatment with partial recovery may have a progression until the end of the fattening process, leaving sequels that cause condemnations at slaughterhouse. These lesions may resemble partly COPD. Conversely, severe fibrinosuppurative pneumonia with chronic course due to unsuccessful treatment may cause death or terminal lesions. These lesions may resemble in part BO/OP. An overlap between these patterns may occur.