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| Target names | Target gene symbol | PANTHER molecular function | Biological process | Pathway categories |
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| Multidrug resistance protein 1 (Pgp, Pgp-170) | ABCB1 | ATPase activity, coupled to transmembrane movement of substances, transmembrane transporter activity | Immune system process, extracellular transport, carbohydrate metabolic process, response to toxin | ATP-binding cassette (ABC) transporter |
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| ATP-binding cassette sub-family G member 2 | ABCG2 | ATPase activity, coupled to transmembrane movement of substances, transmembrane transporter activity, anion channel activity | Immune system process, anion transport, lipid transport, oxygen and reactive oxygen species, metabolic process, lipid metabolic process, response to stress | N/A |
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| Acetyl-coenzyme A carboxylase-α | ACACA | Other ligase | Gluconeogenesis, monosaccharide metabolism, fatty acid biosynthesis, coenzyme metabolism | N/A |
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| α-Fetoprotein | AFP | Other transfer/carrier protein | Transport, mesoderm development, oncogenesis | N/A |
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| Transcription factor AP-1 | AP-1 | DNA binding, transcription factor activity | Cell cycle, intracellular signaling cascade, nucleobase, nucleoside, nucleotide, and nucleic acid, metabolic process, cell cycle, signal transduction | Toll receptor signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, apoptosis signaling pathway, oxidative stress response, angiogenesis, TGF-beta signaling pathway, T-cell activation, B-cell activation, Ras Pathway, FAS signaling pathway, PDGF signaling pathway |
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| Amyloid-β (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | Other signaling molecules | Other signal transduction, cell communication, other intracellular protein traffic | Alzheimer disease-amyloid secretase pathway, Alzheimer disease-presenilin pathway, blood coagulation, Alzheimer disease-presenilin pathway, Alzheimer disease-amyloid secretase pathway |
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| Cyclic AMP-dependent transcription factor ATF-3 | ATF3 | DNA binding, transcription factor activity | Transcription factor activity, immune system process, neurological system process, induction of apoptosis, nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | Apoptosis signaling pathway |
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| Bcl2 antagonist of cell death | BAD | N/A | N/A | PDGF signaling pathway, apoptosis signaling pathway, angiogenesis, PI3 kinase pathway, VEGF signaling pathway, interleukin signaling pathway |
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| BCL2-associated X protein | BAX | Other signaling molecule | Induction of apoptosis, gametogenesis, hematopoiesis, cell cycle control, cell proliferation and differentiation, tumor suppressor | p53 pathway, apoptosis signaling pathway, Huntington disease |
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| B-cell CLL/lymphoma 2 | BCL2 | Other signaling molecule | Inhibition of apoptosis, oncogenesis | Oxidative stress response, apoptosis signaling pathway |
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| Apoptosis regulator Bcl-X | BCL2L1 | Receptor binding | Gamete generation, induction of apoptosis, negative regulation of apoptosis, cell cycle, mesoderm development, hemopoiesis | Apoptosis signaling pathway |
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| B-cell lymphoma 3-encoded protein | Bcl-3 | N/A | Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | Inflammation mediated by chemokine and cytokine signaling pathway |
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| BH3-interacting domain death agonist p11 | BID | N/A | N/A | Apoptosis signaling pathway, FAS signaling pathway |
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| Baculoviral IAP repeat-containing protein 2 (anti-apoptosis factor c-IPA-1) | BIRC2 | N/A | N/A | Apoptosis signaling pathway |
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| Baculoviral IAP repeat-containing protein 3 | BIRC3 | N/A | N/A | Apoptosis signaling pathway |
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| Baculoviral IAP repeat-containing protein 5 (Survivin) | BIRC5 | N/A | N/A | Angiogenesis |
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| Caspase 3, apoptosis-related cysteine peptidase | CASP3 | Cysteine protease | Proteolysis, apoptosis | Huntington disease, FAS signaling pathway, apoptosis signaling pathway |
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| Caspase 8, apoptosis-related cysteine peptidase | CASP8 | Cysteine protease | Proteolysis, apoptosis | Apoptosis signaling pathway, FAS signaling pathway, Huntington disease |
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| Caspase 9, apoptosis-related cysteine peptidase | CASP9 | Cysteine protease | Proteolysis, apoptosis | Angiogenesis, apoptosis signaling pathway, FAS signaling pathway, VEGF signaling pathway, PI3 kinase pathway |
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| Chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) | CCL2 | Nonreceptor serine/threonine, protein kinase | Protein phosphorylation, cell cycle control, mitosis | N/A |
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| G2/mitotic-specific cyclin-B1 | CCNB1 | Protein binding, kinase activator activity, kinase regulator activity | Mitosis | Cell cycle, p53 pathway |
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| G1/S-specific cyclin-D1 | CCND1 | Protein binding, kinase activator activity, kinase regulator activity | Spermatogenesis, mitosis | PI3 kinase pathway, cell cycle, Wnt signaling pathway |
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| G1/S-specific cyclin-D2 | CCND2 | Protein binding, kinase activator activity, kinase regulator activity | Spermatogenesis, mitosis | PI3 kinase pathway, cell cycle |
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| Cyclin E1 | CCNE1 | Kinase activator | Cell cycle control, mitosis, cell proliferation and differentiation | p53 pathway, cell cycle, Parkinson disease, p53 pathway feedback loops 2 |
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| G1/S-specific cyclin-E1 | CCNE1 | Protein binding, kinase activator activity, kinase regulator activity | Mitosis | p53 pathway, cell cycle, Parkinson disease, p53 pathway feedback loops 2 |
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| Interleukin-2 receptor alpha chain | IL2RA/CD25 | Cytokine receptor activity | Immune system process, cell surface receptor-linked signal transduction, intracellular signaling cascade, cell-cell signalling, signal transduction, cell-cell signalling, cellular defense response | Interleukin signaling pathway |
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| Platelet glycoprotein 4 | CD36/FAT | Receptor activity | Macrophage activation, lipid transport, apoptosis, signal transduction, cell adhesion, lipid metabolic process, signal transduction, cell adhesion, cellular component, morphogenesis | N/A |
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| Early activation antigen CD69 | CD69 | Receptor activity, receptor binding | B-cell-mediated immunity, natural killer cell activation, cellular defense response | Membrane-bound signaling molecule |
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| M-phase inducer phosphatase 1 | CDC25A | Hydrolase activity, acting on ester bonds, phosphatase activity | Phosphatase activity cell cycle, phosphate metabolic process, protein metabolic process, cell cycle | p53 pathway |
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| Cdc42 effector protein 1 | CDC42EP1 | N/A | N/A | N/A |
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| Cyclin dependant kinase 1/cell division control protein 2 homolog | CDK1/CDC2 | Kinase activity | Immune system process, mitosis, intracellular signaling cascade, protein metabolic process, cell motion, mitosis, signal transduction, response to stress | p53 pathway |
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| Cyclin-dependent kinase 2 | CDK2 | Nonreceptor serine/threonine protein kinase | Protein phosphorylation, cell cycle control, mitosis | p53 pathway, p53 pathway feedback loops 2 |
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| Cyclin-dependent kinase 4 | CDK4 | Nonreceptor serine/threonine protein kinase | Protein phosphorylation, cell cycle control, mitosis | N/A |
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| Cell division protein kinase 6 | CDK6 | Kinase activity | Immune system process, mitosis, intracellular signaling cascade, protein metabolic process, cell motion, mitosis, signal transduction, response to stress | N/A |
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| Cyclin-dependent kinase inhibitor 1 (p21) | CDKN1A | Protein binding, kinase inhibitor activity, kinase regulator activity | Cell cycle | Interleukin signaling pathway, p53 pathway feedback loops 2, p53 pathway |
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| Cyclin-dependent kinase inhibitor 1B (P27/KIP1) | CDKN1B | Protein binding, kinase inhibitor activity, kinase regulator activity | Cell cycle | Interleukin signaling pathway |
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| CASP8-and FADD-like apoptosis regulator subunit p12 | CFLAR/cFLIP | Peptidase activity, protein binding, peptidase inhibitor activity | Apoptosis, protein metabolic process | Apoptosis signaling pathway, FAS signaling pathway |
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| Inhibitor of NF-κB kinase subunit alpha (IκB kinase) | CHUK(IKK) | Kinase activity | Immune response, intracellular signaling cascade, protein metabolic process, signal transduction, response to stimulus | Interleukin signaling pathway, apoptosis signaling pathway, T-cell activation, toll receptor signaling pathway, B-cell activation |
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| SDF-1-α (3–67) (SDF-1) | CXCL12 | N/A | N/A | Axon guidance-mediated by Slit/Robo |
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| Cytochrome c-1 | CYC1 | Reductase | Oxidative phosphorylation | FAS signaling pathway, ATP synthesis, Huntington disease |
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| Cytochrome P450, family 2, subfamily C, polypeptide 9 | CYP2C9 | Oxygenase | Fatty acid metabolism, steroid metabolism, electron transport | N/A |
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| Cytochrome P450, family 2, subfamily D, polypeptide 6 | CYP2D6 | Oxygenase | Other lipid, fatty acid and steroid metabolism, steroid metabolism, electron transport | Vitamin D metabolism and pathway |
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| Cytochrome P450, family 3, subfamily A, polypeptide 4 | CYP3A4 | Oxygenase | Steroid hormone metabolism, electron transport | N/A |
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| Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | DPP4 | Serine protease | Proteolysis, cell surface receptor mediated signal transduction, T-cell-mediated immunity | N/A |
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| Epidermal growth factor receptor | EGFR | Kinase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane receptor protein kinase activity, receptor binding | Female gamete generation, immune system process, negative regulation of apoptosis, cell cycle, cell surface receptor-linked signal transduction, intracellular signaling cascade, cell-cell signalling, cell-cell adhesion, protein metabolic process, cell motion, cell cyclesignal transduction, cell-cell signalling, dorsal/ventral axis specification, ectoderm development, mesoderm development, embryonic development, nervous system development | EGF receptor signaling pathway, cadherin signaling pathway |
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| Receptor tyrosine-protein kinase erbB-2 | ERBB2/HER2 | Kinase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane receptor protein kinase activity, receptor binding | Female gamete generation, immune system process, negative regulation of apoptosis, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, cell-cell signalling, cell-cell adhesion, protein metabolic process, cell motion, cell cyclesignal transduction, cell-cell signalling, dorsal/ventral axis specification, ectoderm development, mesoderm development, embryonic development, nervous system development | EGF receptor signaling pathway, cadherin signaling pathway |
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| Mitogen-activated protein kinase 3 | ERK1/MAPK3 | Kinase activity | Immune system process, mitosis, cell surface receptor linked signal transduction, intracellular signaling cascade, carbohydrate metabolic process, protein metabolic process, cell motion, signal transduction, segment specification, ectoderm development, mesoderm development, embryonic development, nervous system development, response to stress | Apoptosis signaling pathway, Alzheimer disease-amyloid secretase pathway, B-cell activation, Ras pathway, interleukin signaling pathway, angiogenesis, T-cell activation, toll receptor signaling pathway, insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade, FGF signaling pathway, Parkinson disease, PDGF signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, VEGF signaling pathway, interferon-gamma signaling pathway, endothelin signaling pathway, angiogenesis, TGF-beta signaling pathway, integrin signalling pathway, EGF receptor signaling pathway |
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| Mitogen-activated protein kinase 4 | ERK2/MAPK4 | Kinase activity | Immune system process, mitosis, cell surface receptor linked signal transduction, intracellular signaling cascade, carbohydrate metabolic process, protein metabolic process, cell motion, mitosis, signal transduction, segment specification, ectoderm development, mesoderm development, embryonic development, nervous system development, response to stress | Alzheimer disease-amyloid secretase pathway, interleukin signaling pathway, angiogenesis, VEGF signaling pathway, integrin signalling pathway |
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| Ezrin | EZR | Structural constituent of cytoskeleton | Cellular component, morphogenesis | N/A |
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| C/EBP homologous protein (CHOP) or growth arrest- and DNA damage-inducible gene 153 (GADD153) or DNA damage-inducible transcript 3 | GADD153/DDIT3 | N/A | N/A | Oxidative stress response |
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| Glucagon-like peptide (GCG/GLP-1/GLP-2) | GCG | Receptor binding | Signal transduction, cell-cell signalling, carbohydrate metabolic process, lipid metabolic process, signal transduction, cell-cell signalling, cellular glucose homeostasis | Peptide hormone |
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| Growth/differentiation factor 15 (NAG-1) | GDF15 | Receptor binding | Female gamete generation, cell surface receptor linked signal transduction, signal transduction, ectoderm development, mesoderm development, skeletal system development, heart development, muscle organ development | TGF-beta signaling pathway |
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| Hypoxia-inducible factor 1α | HIF1A | DNA binding, transcription factor activity | Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process, ectoderm development, nervous system development | Hypoxia response via HIF activation, VEGF signaling pathway, angiogenesis |
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| Interferon-β | IFNB1 | Receptor binding | Response to interferon-gamma, induction of apoptosis, negative regulation of apoptosis, cell surface receptor linked signal transduction, intracellular signaling cascade, cell-cell signalling, signal transduction, cell-cell signalling, cellular defense response | Toll receptor signaling pathway |
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| Interleukin-1β | IL1B | Receptor binding | Immune response, macrophage activation, cell surface receptor linked signal transduction, cell-cell signalling, signal transduction, cell-cell signalling, response to stimulus | Inflammation mediated by chemokine and cytokine signaling pathway |
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| Interleukin-6 | IL6 | Receptor binding | Immune system process, negative regulation of apoptosis, cell surface receptor linked signal transduction, intracellular signaling cascade, cell-cell signalling signal transduction, cell-cell signaling | Inflammation mediated by chemokine and cytokine signaling pathway, interleukin signaling pathway |
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| Interleukin 8 | IL8 | Chemokine | Cytokine- and chemokine-mediated signaling pathways, calcium-mediated signalling, NF-kappaB cascade, ligand-mediated signalling, T-cell-mediated immunity, macrophage-mediated immunity, granulocyte-mediated immunity, angiogenesis, cell proliferation and differentiation, cell motility | Inflammation mediated by chemokine and cytokine signaling pathway, interleukin signaling pathway |
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| Potassium voltage-gated channel subfamily H member 2 | KCNH2/HERG1 | Receptor activity, cation transmembrane transporter activity, voltage-gated potassium channel activity, cation channel activity, cyclic nucleotide-gated ion channel activity | Cation transport, signal transduction | Ligand-gated ion channel |
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| Low-density lipoprotein receptor (familial hypercholesterolemia) | LDLR | Other receptor | Oogenesis | Alzheimer disease-presenilin pathway |
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| Mitogen-activated protein kinase 8 (JNK) | MAPK8 | Kinase activity | Immune system process, mitosis, cell surface receptor linked signal transduction, intracellular signaling cascade, carbohydrate metabolic process, protein metabolic process, cell motion, mitosis, signal transduction, segment specification, ectoderm development, mesoderm development, embryonic development, nervous system development, response to stress | Alzheimer disease-amyloid secretase pathway, Ras pathway, EGF receptor signaling pathway, Parkinson disease, angiogenesis, FGF signaling pathway, FAS signaling pathway, toll receptor signaling pathway, TGF-beta signaling pathway, PDGF signaling pathway, Huntington disease, integrin signalling pathway, T-cell activation, B-cell activation, interferon-gamma signaling pathway, oxidative stress response, apoptosis signaling pathway, integrin signalling pathway |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 | Receptor binding | Gamete generation, induction of apoptosis, negative regulation of apoptosis, cell cycle, mesoderm development, hemopoiesis | Apoptosis signaling pathway |
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| Matrix metallopeptidase 1 (27 kDa interstitial collagenase) | MMP1 | Peptidase activity | Protein metabolic process | Plasminogen activating cascade, Alzheimer disease-presenilin pathway, plasminogen activating cascade |
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| Matrix metalloproteinase-16 | MMP16 | Peptidase activity | Protein metabolic process | Alzheimer disease-presenilin pathway |
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| 72 kDa type IV collagenase | MMP2 | Metalloprotease, other extracellular matrix | Proteolysis | Alzheimer disease-presenilin pathway |
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| Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) | MMP9 | Metalloprotease, other extracellular matrix | Proteolysis | Alzheimer disease-presenilin pathway, plasminogen activating cascade |
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| Myc proto-oncogene protein | MYC | DNA binding, transcription factor activity | Induction of apoptosis, cell cycle, nucleobase, nucleoside, nucleotide, and nucleic acid, metabolic process, cell cycle | Oxidative stress response, p53 pathway feedback loops 2, Wnt signaling pathway, interleukin signaling pathway, PDGF signaling pathway |
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| Arylamine N-acetyltransferase 1 | NAT | Acyltransferase activity | Metabolic process | Acetyltransferase |
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| Nuclear factor NF-κB p50 subunit (NF-κB) | NFKB1 | DNA binding, transcription factor activity | B-cell-mediated immunity, negative regulation of apoptosis, intracellular signaling cascade, nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process, signal transduction, cellular defense response | T-cell activation, B-cell activation, toll receptor signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, apoptosis signaling pathway |
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| NF-κB inhibitor-α | NFKBIA | Protein binding | Immune system process, intracellular protein transport apoptosis, intracellular signaling cascade, nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process, signal transduction, response to stress | Apoptosis signaling pathway, toll receptor signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, T-cell activation, B-cell activation |
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| Nucleophosmin (nucleolar phosphoprotein B23) and telomerase | NPM1 | N/A | Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | N/A |
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| Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | NR3C1 | Nuclear hormone receptor, transcription factor, nucleic acid binding | N/A | N/A |
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Poly(ADP-ribose) polymerase family, member 1 | PARP | Glycosyltransferase | DNA repair, protein ADP-ribosylation, stress response | FAS signaling pathway |
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| Proprotein convertase subtilisin/kexin type 9 | PCSK9 | Serine protease | Proteolysis | N/A |
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| Urokinase-plasminogen activator | PLAU | Peptidase activity | Immune system process, signal transduction, protein metabolic process, cell motion, signal transduction, blood coagulation | Blood coagulation, plasminogen activating cascade |
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| Peroxisome proliferator-activated receptor-γ | PPARG | Nuclear hormone receptor, transcription factor, nucleic acid binding | Monosaccharide metabolism, regulation of lipid, fatty acid, and steroid metabolism, mRNA transcription regulation, ligand-mediated signalling, stress response, developmental processes, cell proliferation and differentiation | N/A |
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| Prostaglandin G/H synthase 2 | PTGS2/COX2 | Oxidoreductase activity | Immune system process | Endothelin signaling pathway, toll receptor signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway |
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| Ras-related C3 botulinum toxin substrate 1 | RAC1 | GTPase activity, protein binding | Intracellular protein transport, endocytosis, cell surface receptor linked signal transduction, intracellular signaling cascade, signal transduction | Axon guidance mediated by Slit/Robo, integrin signalling pathway, inflammation mediated by chemokine and cytokine signaling pathway, Huntington disease, axon guidance mediated by Slit/Robo, FGF signaling pathway, T-cell activation, axon guidance mediated by netrin, EGF receptor signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, cytoskeletal regulation by Rho GTPase, aAxon guidance mediated by semaphorins, cytoskeletal regulation by Rho GTPase, B-cell activation, Ras pathway |
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| Rho-associated protein kinase 1 | ROCK1/RHO | Kinase activity | Mitosis, intracellular signaling cascade, cell adhesion, protein metabolic process, cell motion, mitosis, signal transduction, cell adhesion, embryonic development | Inflammation mediated by chemokine and cytokine signaling pathway, cytoskeletal regulation by Rho GTPase |
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| Transforming protein RhoA | RHOA | GTPase activity, protein binding | Intracellular protein transport, endocytosis, cell surface receptor linked signal transduction, intracellular signaling cascade, signal transduction | Axon guidance mediated by Slit/Robo, angiogenesis, heterotrimeric G-protein signaling pathway-Gq alpha; and Go alpha mediated pathway, axon guidance mediated by semaphorins, inflammation mediated by chemokine and cytokine signaling pathway, integrin signalling pathway, Ras pathway, cytoskeletal regulation by Rho GTPase, PDGF signaling pathway |
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| Proto-oncogene tyrosine-protein kinase ROS | ROS1 | Kinase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane receptor protein kinase activity, receptor binding | Female gamete generation, immune system process, visual perception, sensory perception, negative regulation of apoptosis, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, cell-cell signalling, cell-cell adhesion, protein metabolic process, cell motion, cell cycle, signal transduction, ectoderm development, mesoderm development, embryonic development, nervous system development | N/A |
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| Runt-related transcription factor 2 | RUNX2 | DNA binding, transcription factor activity | Mesoderm development, skeletal system development, hemopoiesis | N/A |
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| Sucrase-isomaltase (Alpha-glucosidase) | SI | Hydrolase activity, hydrolyzing O-glycosyl compounds | Carbohydrate metabolic process, protein metabolic process | N/A |
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| Processed sterol regulatory element-binding protein 2 | SREBP2 | DNA binding, transcription factor activity | Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, lipid metabolic process | Basic helix-loop-helix transcription factor |
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| Tumor necrosis factor/tumor necrosis factor-α | TNFA | Tumor necrosis factor family member | Cytokine- and chemokine-mediated signaling pathways, ligand-mediated signalling, immunity and defense, induction of apoptosis | Wnt signaling pathway, apoptosis signaling pathway |
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| Topoisomerase (DNA) I | Top1 | DNA topoisomerase | DNA replication, general mRNA transcription activities | DNA replication |
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| Cellular tumor antigen p53 | TP53 | DNA binding, transcription factor activity | Induction of apoptosis, cell cycle, nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process, cell cycle | Apoptosis signaling pathway, Huntington disease, P53 pathway feedback loops 1, p53 pathway, p53 pathway by glucose deprivation, p53 pathway feedback loops 2, Wnt signaling pathway |
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| Vascular endothelial growth factor A | VEGFA | Receptor binding | Immune system process, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, cell-cell signalling, cell cyclesignal transduction, mesoderm development, angiogenesis, response to stress | Angiogenesis, VEGF signaling pathway |
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| Wee1-like protein kinase | Wee1 | Kinase activity | Mitosis, protein metabolic process | Protein kinase |
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