The Scientific World Journal

Research Article

Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives

Table 1

Open-field exploratory test.
GroupsAmbulationRearingFecal pelletsFreezing time
Control 1 3 3 . 7 ± 0 . 6 6 6 7 1 9 . 5 3 ± 0 . 2 1 8 6 0 . 7 ± 0 . 3 9 3 0 5 1 . 5 3 ± 0 . 1 4 5 3
Ethidium
Bromide 8 7 . 6 7 ± 6 . 9 6 0 1 3 . 0 ± 1 . 1 5 5 * 3 ± 0 . 5 7 7 4 * 6 8 . 5 3 ± 0 . 2 0 2 8
Antioxidant 1 0 8 . 2 ± 2 . 0 8 3 *** 2 5 . 2 ± 1 . 5 3 0 ** 3 . 8 ± 0 . 2 0 0 0 ** 5 8 . 4 8 ± 0 . 6 7 5 ***
Comp2a 1 1 5 . 8 ± 0 . 3 7 4 2 ** 2 6 . 4 ± 0 . 0 5 0 ** 3 . 2 ± 0 . 4 8 9 4 0 . 5 0 ± 0 . 5 1 1 7 ***
Comp2b 1 0 9 . 4 ± 0 . 3 3 5 *** 3 3 . 6 ± 0 . 7 4 3 *** 3 ± 0 . 5 4 7 7 ** 4 3 . 4 6 ± 0 . 1 5 3 6 ***
Comp2c 1 5 3 . 4 ± 0 . 6 0 0 0 *** 3 9 . 4 2 ± 0 . 1 5 9 *** 3 . 6 ± 0 . 6 7 8 2 ** 4 6 . 2 8 ± 0 . 1 0 2 0 ***
𝑃 < 0 . 0 5 ; ***extremely significant; **moderately significant; *significant.