The Scientific World Journal / 2012 / Article / Fig 3

Review Article

Chronic-Alcohol-Abuse-Induced Oxidative Stress in the Development of Acute Respiratory Distress Syndrome

Figure 3

Glutathione synthesis, transportation, and compartmentalization. (a) GSH de novo synthesis requires glutamate (Glu), cysteine (Cys), and glycine (Gly). Key enzymes involved are g-GT: g-glutamyltransferase; g-GCS: γ-glutamylcysteinesynthetase; GS: glutathionsynthetase. GSH is freely distributed in the cytosol, but also compartmentalized in mitochondria, nucleus and ER. (b) GSH transports from cytosol to mitochondrion. GSH can move easily through the mitochondrial outer membrane, but requires carrier-mediated transport to cross the mitochondrial inner membrane. DCC: dicarboxylate carrier; OGC: 2-oxoglutarate carrier.
740308.fig.003a
(a)
740308.fig.003b
(b)

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.