Chronic-Alcohol-Abuse-Induced Oxidative Stress in the Development of Acute Respiratory Distress Syndrome

<table>Ethanol impaired mitochondrial GSH (a) and 2-oxoglutarate (b) uptake. The investigation of mitochondrial uptake of GSH and 2-oxoglutarate revealed that procysteine (PRO) but not N-acetylcysteine (NAC) protected the 2-oxoglutarate transporter during ethanol ingestion. The uptakes of <sup>3</sup>H-GSH and <sup>14</sup>C-oxoglutarate were assessed in mitochondria isolated from alveolar type II cells from rats fed control, ethanol, ethanol + NAC, or ethanol + PRO diets. (*<svg height="11.85" id="M5" style="vertical-align:-0.546pt" version="1.1" viewbox="0 0 58.712502 11.85" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) compared to controls.</table>

The Scientific World Journal

fig4

Figure 4

Figure 4: Chronic-Alcohol-Abuse-Induced Oxidative Stress in the Development of Acute Respiratory Distress Syndrome 