Population Pharmacokinetics of Vancomycin in Thai Patients

Table 2

Population pharmacokinetic parameters of vancomycin in Thai patients estimated from final model.

Parameter	Mean estimate	Estimation error^a (%)
Fixed parameters
CL(L/h)=𝜃1×CLCr (mL/min)
𝜃1	0.044	22.34
𝑉1(L)=𝜃2×Age (years old)
𝜃2	0.542	16.00
𝑄(L/h)=𝜃3
𝜃3	6.950	45.17
𝑉2(L)=𝜃4
𝜃4	44.200	19.58
Interindividual variability
𝜔CL (%)	35.78	20.00
𝜔𝑉1 (%)	20.93	120.00
𝜔𝑄 (%)	39.50	346.67
𝜔𝑉2 (%)	57.27	75.47
Intraindividual variability
𝜎 (mg/L)	4.51	38.07

^aExpressed as a coefficient of variation.
CL, vancomycin clearance; 𝑉₁, volume of the central compartment of vancomycin; 𝑄, vancomycin intercompartmental clearance; 𝑉₂, volume of the peripheral compartment of vancomycin; CL_Cr, creatinine clearance by Cockcroft-Gault equation; 𝜔, interindividual variability related to PK parameter; 𝜎, intraindividual variability.