Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells

Figure 3

Differentiation of mesenchymal stem cells towards adipocytes. Peroxisome proliferator-activated receptor gamma (PPARγ) commits MSCs towards adipogenic lineage. Preadipocyte factor 1 (Pref-1) and GATA binding protein 2 (Gata2) are expressed in preadipocyte. In early adipocyte determination and differentiation factor (ADD1), CCAAT/enhancer binding protein beta (C/EBPβ), Kruppel-like factor 5 (KLF5), PPARγ, lipoprotein lipase (LPL), leptin and adiponectin are expressed. The early adipocyte develops into the adipocyte that expresses PPARγ, C/EBPα adiponectin, adipsin, adipocyte protein 2, and purinergic receptor P2Y 11 (P2Y11).