Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012 (2012), Article ID 810234, 5 pages
http://dx.doi.org/10.1100/2012/810234
Clinical Study

A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children

1Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran
2Department of Pediatrics, Kashan University of Medical Sciences, P.O. Box 88175-111, Kashan, Iran
3Department of Infectious Diseases, Kashan University of Medical Sciences, P.O. Box 88175-111, Kashan, Iran
4Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran
5Pharmaceutical Sciences Branch, Islamic Azad University, P.O. Box 19945-581, Tehran, Iran
6Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences (MUMS), P.O. Box 91775-1365, Mashhad, Iran

Received 25 October 2011; Accepted 21 November 2011

Academic Editors: V. Cechinel-Filho and A. Tubaro

Copyright © 2012 Yunes Panahi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children. Methods. Sixty-six infants with DD (aged < 3 years) were randomized to receive either Aloe cream ( 𝑛 = 3 2 ) or Calendula ointment ( 𝑛 = 3 4 ). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. Results. Although improvement in the severity of DD was observed in both treatment groups ( 𝑃 < 0 . 0 0 1 ), patients receiving Calendula ointment had significantly fewer rash sites compared to Aloe group ( 𝑃 = 0 . 0 0 1 ). No adverse effect was reported from either of the medications. Discussion. The evidence from this study suggests that topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.