The Scientific World Journal / 2012 / Article / Tab 3 / Research Article
Regulating Drug Release Behavior and Kinetics from Matrix Tablets Based on Fine Particle-Sized Ethyl Cellulose Ether Derivatives: An In Vitro and In Vivo Evaluation Table 3 Values of physicochemical parameters applied to CR tablets of ciprofloxacin HCl.
S/no. Parameter 10 : 1 10 : 2 10 : 3 10 : 4 10 : 5 10 : 6 10 : 7 10 : 8
(
1
)
Weight variation (mg) 202.3 201.7 199.8 202.4 200.9 201.3 203.4 203.2
(
2
)
Friability (%)
0
.
3
1
±
0
.
1
7
0
.
3
8
±
0
.
2
1
0
.
3
4
±
0
.
1
9
0
.
2
7
±
0
.
0
9
0
.
3
9
±
0
.
2
2
0
.
2
2
±
0
.
0
7
0
.
1
7
±
0
.
0
4
0
.
3
8
±
0
.
2
1
(
3
)
Hardness (kg/cm2 )
6
.
7
±
0
.
1
3
6
.
4
±
0
.
1
2
6
.
9
±
0
.
1
6
6
.
8
±
0
.
1
5
7
.
1
±
0
.
1
8
6
.
9
±
0
.
1
3
7
.
0
±
0
.
1
7
6
.
8
±
0
.
1
5
(
4
)
Diameter (mm)
8
±
0
.
0
7
8
±
0
.
0
5
8
±
0
.
0
7
8
±
0
.
0
7
8
±
0
.
0
4
8
±
0
.
0
6
8
±
0
.
0
8
8
±
0
.
0
7
(
5
)
Thickness (mm)
2
.
7
±
0
.
0
9
2
.
7
±
0
.
0
9
2
.
8
±
0
.
0
8
2
.
6
±
0
.
0
5
2
.
6
±
0
.
0
6
2
.
7
±
0
.
0
8
2
.
7
±
0
.
0
6
2
.
5
±
0
.
0
5
(
6
)
Drug content (%) 98.3 97.8 102.1 97.5 98.9 101.3 99.5 98.7
