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The Scientific World Journal
Volume 2012, Article ID 879158, 8 pages
Research Article

Correlation of Surgical Pleth Index with Stress Hormones during Propofol-Remifentanil Anaesthesia

1Department of Anaesthesia, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China
2Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schleswig-Holstein, 24105 Kiel, Germany

Received 25 June 2012; Accepted 18 July 2012

Academic Editors: N. J. Christensen and E. O. Martin

Copyright © 2012 Xinzhong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Eighty patients undergoing elective ear-nose-throat surgery were enrolled in the present study to investigate the relationship between surgical pleth index (SPI) and stress hormones (ACTH, cortisol, epinephrine, norepinephrine) during general anaesthesia which was induced and maintained with propofol and remifentanil using a target-controlled infusion. The study concluded that the SPI had moderate correlation to the stress hormones during general anaesthesia, but no correlation during consciousness. Furthermore, SPI values were able to predict ACTH values with high sensitivity and specificity.