Clinical Study
The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population
Table 4
Genotyping and allele frequency of ORAI1ββgene in patients with breast cancer with different estrogen receptor (ER) status.
| | | Positive (%) | Negative (%) | | Positive (%) | Negative (%) | Dominant | Recessive | Allelic | | Genotype | () | () | Allele | () | () | P value | P value | P value |
| | rs12320939 | TT | 58 (24.6) | 17 (13.1) | T | 226 (47.9) | 113 (43.5) | 0.5870 | 0.0091
**
| 0.2511 | | TG | 110 (46.6) | 79 (60.8) | G | 246 (52.1) | 147 (56.5) | | | | | GG | 68 (28.8) | 34 (26.1) | | | | | | | | rs12313273 | CC | 20 (8.5) | 2 (1.5) | C | 134 (28.6) | 58 (21.8) | 0.2220 | 0.0063
**
| 0.0430
*
| | CT | 94 (40.2) | 54 (40.6) | T | 334 (71.4) | 208 (78.2) | | | | | TT | 120 (51.3) | 77 (57.9) | | | | | | | | rs7135617 | TT | 37 (16.2) | 20 (15.6) | T | 186 (40.8) | 116 (45.3) | 0.0593 | 0.8816 | 0.2413 | | TG | 112 (49.1) | 76 (59.4) | G | 270 (59.2) | 140 (54.7) | | | | | GG | 79 (34.7) | 32 (25.0) | | | | | | | | rs6486795 | CC | 31 (13.3) | 10 (7.8) | C | 170 (36.5) | 91 (35.3) | 0.5586 | 0.1104 | 0.7455 | | CT | 108 (46.4) | 71 (55.0) | T | 296 (63.5) | 167 (64.7) | | | | | TT | 94 (40.3) | 48 (37.2) | | | | | | | | rs712853 | CC | 25 (10.7) | 11 (8.2) | C | 156 (33.5) | 84 (31.3) | 0.7459 | 0.4344 | 0.5531 | | CT | 106 (45.5) | 62 (46.3) | T | 310 (66.5) | 184 (68.7) | | | | | TT | 102 (43.8) | 61 (45.5) | | | | | | |
|
|
*
is labeled in bold. ** is labeled in bold.
|
