One-Pot Synthesis of β-Acetamido Ketones Using Boric Acid at Room Temperature

Table 1

Synthesis of β-acetamido ketones using boric acid.

Entry	R	R′	Product	Time (h)	Yield (%)
1	H	H	3a	1.5	95
2	H	4-Cl	3b	1.5	90
3	H	4-NO2	3c	3.5	97
4	H	4-CH3	3d	2	85
5	4-Cl	H	3e	2	88
6	4-Cl	4-Cl	3f	2	88
7	4-Cl	4-NO2	3g	2	90
8	4-Cl	4-CH3	3h	1.5	88
9	4-CH3	H	3i	1.5	95
10	4-CH3	4-CH3	3j	2	92
11	4-CH3	4-NO2	3k	2	98
12	3-NO2	H	3l	3	90
13	3-NO2	4-Cl	3m	3.5	92
14	4-NO2	H	3n	3.5	91
15	4-NO2	4-Cl	3o	2	92
16	4-NO2	4-NO2	3p	3	87
17	4-OH	H	3q	0.5	80
18	4-CH3O	H	3r	0.5	86
19	2,3-Cl2	H	3s	2.5	87
20	2,3-Cl2	4-Cl	3t	2	92
21	2,4-Cl2	4-NO2	3u	3.5	85
22	2,6-Cl2	H	3v	3	80
23	2-Cl-6-F	H	3w	4.5	80
24	2-Cl-6-F	4-NO2	3x	4	88
25	4-Cl-3-NO2	H	3y	2	90