Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex

Table 2

Ligands, functions and protein sequence conservation of members of the DECTIN-1 cluster.

	Ligand	Function	% Sequence identity to human protein
			Chimp	Cow	Mouse	Dog	Platypus	Opossum
DECTIN-1	β-glucan	Phagocytosis, cytokine production, antifungal immune defense	98	74	61	74	—	—
LOX-1	Modified lipoproteins, apoptotic cells, bacteria	Endocytosis, phagocytosis, apoptosis, cytokine production, ROS production, implications in vascular disease	99	73	61	74	35	—
CLEC-1	Unknown	Putative regulatory function	99	76	70	75	—	74 (CTLD only)
CLEC-2	Rhodocytin, podoplanin	Platelet activation, implications in tumor metastasis, lymphatic/blood vessel separation during development, phagocytosis, cytokine production	97	69	65	70	—	74 (CTLD only)
CLEC9A	Unknown ligand on necrotic cells	Cross-presentation of dead-cell-associated antigens to T cells	99	71	60	72	—	—
CLEC12B	Unknown	Putative inhibitory function	?	80	72	81	26	—

Sequence identity to the human ortholog was obtained using the NCBI HomoloGene tool (available at: http://www.ncbi.nlm.nih.gov/sites/entrez?db=homologene).