Model of regulation of gap junctional communication (GJ, Cx43) [6, 8, 9] During development of the antral follicles FSH hormone stimulates mRNA expression that codifies the Cx43 synthesis of the GJs, the amplification of functional channels, and consequently the integration to the metabolic activity [8]. Mediated by the family mitogen-activated protein kinases, preovulatory LH levels interrupt cell-cell communications by means of phosphorylation and modification of Cx43 protein conformation. This leads to interruption of the intercellular channels. The primary effect of the immediate response to LH is accompanied by elimination of the Cx43 protein, disappearance of GJ sand separation of the GCs from the oocyte. GJ: gap junction; GC: granulosa cells. With permission from N. Dekel.
