Oral Vaccination Based on DNA-Chitosan Nanoparticles against Schistosoma mansoni Infection
Figure 4
Serum anti-rSmRho-specific IgG levels of mice immunized orally with DNA (a) or CHimi-DNA (b) and intramusculary with CHimi-DNA nanoparticles (c). Sera of immunized mice were collected at days 15 (one week after the first immunization), 30, 45, 60, 75, and 95 and assayed by ELISA. The results are presented as the mean absorbance measured at 450 nm for each group. Statistically significant differences of vaccinated mice compared with the control group, PBS, in each time evaluated, are indicated by (*) for .
