Oral Vaccination Based on DNA-Chitosan Nanoparticles against Schistosoma mansoni Infection
Figure 5
Cytokine profiles of mice immunized with CH-DNA nanoparticles. Splenocytes isolated from mice immunized with Chimi-DNA nanoparticles (a), CHimi-DNA (i.m.) (b), DNA (c), or CH (d) were assayed as IL-10 (A), IL-4 (B) and INF-γ (C), production in response to in vitro stimulation with SWAP (25 μg/mL), rSmRho (25 μg/mL), SEA (25 μg/mL), or medium alone as control. Results represent the mean ± SD of each group. *Statistically significant differences between cytokines produced after SWAP, rSmRho, or SEA stimulation compared with unstimulated splenocytes (control) ().
