Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012 (2012), Article ID 938457, 11 pages
http://dx.doi.org/10.1100/2012/938457
Research Article

Oral Vaccination Based on DNA-Chitosan Nanoparticles against Schistosoma mansoni Infection

1Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos 6627, ICB Q4-167, 31270-901 Belo Horizonte, MG, Brazil
2Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal
3Faculdade de Farmácia, Universdade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
4Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal

Received 30 October 2011; Accepted 29 November 2011

Academic Editors: M. A. Bayomi and K. M. Vårum

Copyright © 2012 Carolina R. Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World health organization (WHO), Schistosomiasis, F.d.i. 115, Editor. 2010.
  2. M. J. Van Der Werf, S. J. De Vlas, S. Brooker et al., “Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa,” Acta Tropica, vol. 86, no. 2-3, pp. 125–139, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Steinmann, J. Keiser, R. Bos, M. Tanner, and J. Utzinger, “Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk,” Lancet Infectious Diseases, vol. 6, no. 7, pp. 411–425, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Harder, “Chemotherapeutic approaches to schistosomes: current knowledge and outlook,” Parasitology Research, vol. 88, no. 5, pp. 395–397, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. K. R. Matthews, “Controlling and coordinating development in vector-transmitted parasites,” Science, vol. 331, no. 6021, pp. 1149–1153, 2011. View at Publisher · View at Google Scholar
  6. C. H. King, “Global health: toward the elimination of schistosomiasis,” New England Journal of Medicine, vol. 360, no. 2, pp. 106–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Bergquist, “Prospects for schistosomiasis vaccine development,” TDR News, vol. 71, pp. 6–7, 2004. View at Google Scholar
  8. L. Chitsulo, P. Loverde, and D. Engels, “Schistosomiasis,” Nature Reviews Microbiology, vol. 2, no. 1, pp. 12–13, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. S. C. Oliveira, C. T. Fonseca, F. C. Cardoso, L. P. Farias, and L. C. C. Leite, “Recent advances in vaccine research against schistosomiasis in Brazil,” Acta Tropica, vol. 108, no. 2-3, pp. 256–262, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Schüssler, C. G. Grevelding, and W. Kunz, “Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male-female interaction,” Parasitology, vol. 115, no. 6, pp. 629–634, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. I. K. Loeffler and J. L. Bennett, “A rab-related GTP-binding protein in Schistosoma mansoni,” Molecular and Biochemical Parasitology, vol. 77, no. 1, pp. 31–40, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. J. E. Ledgerwood and B. S. Graham, “DNA vaccines: a safe and efficient platform technology for responding to emerging infectious diseases,” Human Vaccines, vol. 5, no. 9, pp. 623–626, 2009. View at Google Scholar · View at Scopus
  13. R. G. Whalen, “DNA vaccines for emerging infectious diseases: what if?” Emerging Infectious Diseases, vol. 2, no. 3, pp. 168–175, 1996. View at Google Scholar
  14. A. Bozkir and O. M. Saka, “Chitosan nanoparticles for plasmid DNA delivery: effect of chitosan molecular structure on formulation and release characteristics,” Drug Delivery, vol. 11, no. 2, pp. 107–112, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. A. K. Singla and M. Chawla, “Chitosan: some pharmaceutical and biological aspects—an update,” Journal of Pharmacy and Pharmacology, vol. 53, no. 8, pp. 1047–1067, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Ranaldi, I. Marigliano, I. Vespignani, G. Perozzi, and Y. Sambuy, “The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line,” Journal of Nutritional Biochemistry, vol. 13, no. 3, pp. 157–167, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Q. Mao, K. Roy, V. L. Troung-Le et al., “Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency,” Journal of Controlled Release, vol. 70, no. 3, pp. 399–421, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. I. M. Van Der Lubben, J. C. Verhoef, A. C. Van Aelst, G. Borchard, and H. E. Junginger, “Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches,” Biomaterials, vol. 22, no. 7, pp. 687–694, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Roy, H. Q. Mao, S. K. Huang, and K. W. Leong, “Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy,” Nature Medicine, vol. 5, no. 4, pp. 387–391, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Moreira, H. Oliveira, L. R. Pires, S. Simões, M. A. Barbosa, and A. P. Pêgo, “Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone,” Acta Biomaterialia, vol. 5, no. 8, pp. 2995–3006, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. H. C. Arca, M. Günbeyaz, and S. Şenel, “Chitosan-based systems for the delivery of vaccine antigens,” Expert Review of Vaccines, vol. 8, no. 7, pp. 937–953, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Brugnerotto, J. Lizardi, F. M. Goycoolea, W. Argüelles-Monal, J. Desbrières, and M. Rinaudo, “An infrared investigation in relation with chitin and chitosan characterization,” Polymer, vol. 42, no. 8, pp. 3569–3580, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. “United States Pharmacopeia,” in General Chapter 85—Bacterial Endotoxins Test, 2005.
  24. S. R. Smithers and R. J. Terry, “The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms,” Parasitology, vol. 55, no. 4, pp. 695–700, 1965. View at Google Scholar · View at Scopus
  25. H. H. Marques, C. S. Zouain, C. B. B. Torres, J. S. Oliveira, J. B. Alves, and A. M. Goes, “Protective effect and granuloma down-modulation promoted by RP44 antigen a fructose 1,6 bisphosphate aldolase of Schistosoma mansoni,” Immunobiology, vol. 213, no. 5, pp. 437–446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. Goes, R. S. Rocha, G. Gazzinelli, and B. L. Doughty, “Production and characterization of human monoclonal antibodies against Schistosoma mansoni,” Parasite Immunology, vol. 11, no. 6, pp. 695–711, 1989. View at Google Scholar · View at Scopus
  27. M. C. Schneider, X. P. Aguilera, J. B. da Silva Junior et al., “Elimination of neglected diseases in Latin America and the Caribbean: a mapping of selected diseases,” PLoS Neglected Tropical Diseases, vol. 5, no. 2, article e964, 2011. View at Publisher · View at Google Scholar
  28. C. N. Kotton and E. L. Hohmann, “Enteric pathogens as vaccine vectors for foreign antigen delivery,” Infection and Immunity, vol. 72, no. 10, pp. 5535–5547, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Illum, “Chitosan and its use as a pharmaceutical excipient,” Pharmaceutical Research, vol. 15, no. 9, pp. 1326–1331, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Mansouri, P. Lavigne, K. Corsi, M. Benderdour, E. Beaumont, and J. C. Fernandes, “Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 57, no. 1, pp. 1–8, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Gao, W. Shi, and L. B. Freund, “Mechanics of receptor-mediated endocytosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 27, pp. 9469–9474, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Chen, J. M. Mccrate, J. C.-M. Lee, and H. Li, “The role of surface charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cells,” Nanotechnology, vol. 22, no. 10, 2011. View at Publisher · View at Google Scholar
  33. G. Z. Chen and J. L. Bennett, “Characterization of mevalonate-labeled lipids isolated from parasite proteins in Schistosoma mansoni,” Molecular and Biochemical Parasitology, vol. 59, no. 2, pp. 287–292, 1993. View at Publisher · View at Google Scholar · View at Scopus
  34. M. S. Wilson, M. M. Mentink-Kane, J. T. Pesce, T. R. Ramalingam, R. Thompson, and T. A. Wynn, “Immunopathology of schistosomiasis,” Immunology and Cell Biology, vol. 85, no. 2, pp. 148–154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Hesse, C. A. Piccirillo, Y. Belkaid et al., “The pathogenesis of Schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells,” Journal of Immunology, vol. 172, no. 5, pp. 3157–3166, 2004. View at Google Scholar · View at Scopus
  36. T. A. Wynn, A. W. Cheever, M. E. Williams et al., “IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease,” Journal of Immunology, vol. 160, no. 9, pp. 4473–4480, 1998. View at Google Scholar · View at Scopus
  37. J. C. Todt, J. R. Whitfield, S. R. Ivard, and D. L. Boros, “Down-regulation of interleukin-12, interleukin-12r expression/ activity mediates the switch from Th1 to Th2 granuloma response during murine Schistosomiasis mansoni,” Scandinavian Journal of Immunology, vol. 52, no. 4, pp. 385–392, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. K. F. Hoffmann, A. W. Cheever, and T. A. Wynn, “IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis,” Journal of Immunology, vol. 164, no. 12, pp. 6406–6416, 2000. View at Google Scholar · View at Scopus
  39. A. K. Nyame, F. A. Lewis, B. L. Doughty, R. Correa-Oliveira, and R. D. Cummings, “Immunity to schistosomiasis: glycans are potential antigenic targets for immune intervention,” Experimental Parasitology, vol. 104, no. 1-2, pp. 1–13, 2003. View at Publisher · View at Google Scholar · View at Scopus