HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients
Table 1
Two procedures for evaluation of HER-2 expression.
Percentage of positive cells
IRS (Immunoreactive Score) modified by authorsa
Points
Points
Intensity of reaction
No positive cells
0
No reaction
0
<25% positive cells
1
Weak colour reaction
1
25–50% positive cells
2
Moderate intensity
2
51–75% positive cells
3
Intense reaction
3
>75% positive cells
4
Consensus recommendations on HER-2 scoring for gastric cancerb
Definition
Score
No reactivity or membranous reaction in <10% of cells
0
Faint complete or partial membranous reactivity in >10% of cells
1+
Moderate complete or basolateral membranous reactivity in >10% of cells
2+
Strong complete or basolateral membranous reactivity in >10% of cells
3+
a IRS score (Immunoreactive Score) according to Remmele and Stegner [15] modified by authors
bHercep test criteria modified by Hofmann et al. [16] for gastric cancer.