HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

Table 2

Parameters of HER-2 immunoreactivity.

Immunohistochemical parameters	Score/points	N (%)	Interpretation
Hercep test score^a	0	35 (44.9)	Negative
	1+	20 (25.6)	Negative
	2+	17 (21.8)	Overexpression
	3+	6 (7.7)	Overexpression
Percentage of positive HER-2 cancer cells (%)^b	0	35 (44.9)
	1	12 (15.4)
	2	10 (12.8)
	3	10 (12.8)
	4	11 (14.1)
Intensity of HER-2 reaction (I)^c	0	35 (44.9)
	1	15 (19.2)
	2	21 (26.9)
	3	7 (9.0)
HER-2 IRS^d	0-1	42 (53.8)	Negative
	2-3	12 (15.4)	Negative
	4–8	20 (25.6)	Overexpression
	9–12	4 (5.2)	Overexpression

^aHercep test criteria modified by Hofmann et al. [16] for gastric cancer.
^bPercentage of HER-2 positive gastric cancer cells (%) according to Remmele and Stegner [15] modified by authors.
^cIntensity of immunohistochemical reaction in cancer cells (I) according to Remmele and Stegner [15] modified by authors.
^dIRS score (Immunoreactive Score) according to Remmele and Stegner [15] modified by authors.