HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

Table 3

Correlations between HER-2 expression and clinicopathological parameters.

Clinicopathological parameters	Hercep test^a,b	HER-2%^a,c	HER-2 I^a,d	HER-2 IRS^a,e
Tumor size (pT)	0.211	0.454	0.389	0.193
Nodal metastases (pN+)	0.945	0.736	0.702	0.750
Grading	0.064	0.212	0.189	0.202
Lauren’s classification	0.505	0.835	0.692	0.554
Age^f	0.570	0.935	0.693	0.693
Ulceration	0.672	0.035	0.162	0.074
Tumor infiltrating lymphocytes	0.839	0.889	0.717	0.852

^a𝑃 value of Chi² test.
^bHercep test criteria modified by Hofmann et al. [16] for gastric cancer.
^cPercentage of HER-2-positive gastric cancer cells (%) according to Remmele and Stegner [15] modified by authors.
^dIntensity of immunohistochemical reaction in cancer cells (I) according to Remmele and Stegner [15] modified by authors.
^eIRS score (ImmunoReactive Score) according to Remmele and Stegner [15] modified by authors.
^fSpearman’s rank correlation.