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The Scientific World Journal
Volume 2012 (2012), Article ID 947907, 10 pages
http://dx.doi.org/10.1100/2012/947907
Clinical Study

Aortic Stiffness, Left Ventricle Hypertrophy, and Homogeneity of Ventricle Repolarization in Adult Dialyzed Patients

1Chair and Department of Cardiology, Medical University of Lublin, ul. Jaczewskiego 8, 20–954 Lublin, Poland
2Chair and Department of Family Medicine, Medical University of Lublin, ul. Staszica 11, 20–081 Lublin, Poland
3Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, ul. Jaczewskiego 8, 20–954 Lublin, Poland
4First Chair and Department of General and Transplant Surgery, and Clinical Nutrition, Medical University of Lublin, ul. Jaczewskiego 8, 20–954 Lublin, Poland
5Chair and Department of Nephrology, Medical University of Lublin, ul. Jaczewskiego 8, 20–954 Lublin, Poland

Received 22 October 2011; Accepted 8 December 2011

Academic Editor: Shijie Sun

Copyright © 2012 Tomasz Zapolski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Study was designed to assess relationship between aortic compliance and homogeneity of heart electrical activity in dialysis patients. Methods. Study group was consisted of 120 dialyzed patients; 57 (age 5 0 , 7 Β± 7 , 1 ) were on continuous ambulatory peritoneal dialysis (CAPD) and 73 (age 5 1 , 6 Β± 7 , 6 ) were hemodialyzed (HD). Three-dimensional vectorocardiographic (VCG) monitoring was done to assess: QRS- 𝑇 a n g l e , 𝑇 e l and 𝑇 a z . Echocardiography was performed to assess: A o m a x , A o m i n , ASI (aortic siffness index). Results. ASI in HD as well as in CAPD patients was significantly higher compared to controls [resp., 5,51 (±1,32), 5,83 (±1,41), 3,07 (±1,09)]. Cut-off value of ASI was 5,67. In HD patients strong correlations between ASI and QRS- 𝑇 a n g l e , 𝑇 e l and 𝑇 a z were determined (resp., π‘Ÿ = 0 , 4 2 9 , 𝑃 < 0 , 0 0 1 ; π‘Ÿ = 0 , 4 3 2 , 𝑃 ≀ 0 , 0 0 1 and π‘Ÿ = 0 , 3 8 7 , 𝑃 = 0 , 0 0 1 ). In CAPD group were significant association between ASI and QRS- 𝑇 a n g l e , 𝑇 e l and 𝑇 a z (resp., π‘Ÿ = 0 , 4 5 2 , 𝑃 < 0 , 0 0 1 ; π‘Ÿ = 0 , 4 1 7 , 𝑃 < 0 , 0 0 1 and π‘Ÿ = 0 , 3 9 0 , 𝑃 = 0 , 0 0 1 ). ASI was independently and markedly associated with: QRS- 𝑇 a n g l e , 𝑇 e l e v , 𝑇 a z , ADMA, cTnT, CRP, Total-chol, LDL-chol in HD and CAPD patients. Conclusions. ASI and VCG indices are higher in HD and CAPD patients. Correlation between ASI and VCG parameters may reflect unfavourable influence of poor aortic compliance on the electrical activity of the heart in dialyzed patients. Hypertrophy aggravates repolarization disturbances in hemodialyzed patients.