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The Scientific World Journal
Volume 2012, Article ID 954934, 8 pages
Research Article

Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities

Department of Chemistry, Punjabi University, Punjab, Patiala147002, India

Received 31 October 2011; Accepted 5 December 2011

Academic Editors: R. Dalpozzo and G. Sommen

Copyright © 2012 Mohamad Yusuf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The diisochromenochromen-4-one 3a-3b, 4a-4c, 5a-6a  & 7 have been prepared from the photocyclization reaction of bischromen-4-one 2a-2e. The later compounds are obtained from the O-alkylation of the suitable 3-hydroxy-2-aryl-4H-chromen-4-one 1a-1e with 4,4′-bischloromethyl-diphenyl in dry acetone, anhydrous K2CO3, and PTC (Bu4N+I) under refluxing conditions. The structures of compounds 2a-2e, 3a-3b, 4a-4c, 5a-6a  & 7 have been characterized from the rigorous analysis of their IR, 1H-NMR, 13C-NMR, ESI-Mass, and elemental analysis. The antibacterial and antifungal activities of the synthesized products were also evaluated against the Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Aspergillus janus and Penicillium glabrum, respectively. Some of the tested compounds showed significant activity against the above-said microorganisms.