Table of Contents Author Guidelines Submit a Manuscript
Erratum

An erratum for this article has been published. To view the erratum, please click here.

The Scientific World Journal
Volume 2012 (2012), Article ID 957126, 6 pages
http://dx.doi.org/10.1100/2012/957126
Clinical Study

Reinstitution of Mechanical Ventilation within 14 Days as a Poor Predictor in Prolonged Mechanical Ventilation Patients following Successful Weaning

1Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
2Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan

Received 29 January 2012; Accepted 22 March 2012

Academic Editors: G. Nieman, S. T. Venkataraman, and J.-L. Vincent

Copyright © 2012 Mei-Lien Tu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although many parameters were investigated about weaning and mortality in critical patients in intensive units, no studies have yet investigated predictors in prolonged mechanical ventilation (PMV) patients following successful weaning. A cohort of 142 consecutive PMV patients with successful weaning in our respiratory care center was enrolled in this study. Successful weaning is defined as a patient having smooth respiration for more than 5 days after weaning. The results showed as follows: twenty-seven patients (19%) had the reinstitution within 14 days, and 115 patients (81%) had the reinstitution beyond 14 days. Renal disease RIFLE-LE was associated with the reinstitution within 14 days ( 𝑃 = 0 . 0 0 6 ). One year mortality rates showed significant difference between the two groups (85.2% in the reinstitution within 14 days group versus 53.1% in the reinstitution beyond 14 days; 𝑃 < 0 . 0 0 1 ). Kaplan-Meier analysis showed that age ≥70 years ( 𝑃 = 0 . 0 4 ), ESRD ( 𝑃 = 0 . 0 2 ), and the reinstitution within 14 days ( 𝑃 < 0 . 0 0 1 ) were associated with one-year mortality. Cox proportional hazards regression model showed that only the reinstitution within 14 days was the independent predictor for mortality ( 𝑃 < 0 . 0 0 1 ). In conclusion, the reinstitution within 14 days was a poor predictor for PMV patients after successful weaning.