Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats
Figure 4
Resting mean heart rate (min−1) in Wistar rats fed hypercholesterolaemic diet. K_H: hypercholesterolaemic control group, IW_H: hypercholesterolaemic group receiving ivabradine, S1_H: hypercholesterolaemic group receiving simvastatin at a dose of 1 mg × kg−1 bw, S20_H: hypercholesterolaemic group receiving simvastatin at a dose of 20 mg × kg−1 bw, IW_H_S1-hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg−1 bw, IW_H_S20: hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg−1 bw, as compared to control group, (a) as compared to rats receiving simvastatin alone, and (b) as compared to rats receiving ivabradine alone, (c) as compared to rats receiving ivabradine and simvastatin at a dose of 1 mg × kg−1 bw.