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The Scientific World Journal
Volume 2012 (2012), Article ID 979867, 5 pages
Research Article

Prevalence of Clinically Significant Extraosseous Findings on Unenhanced CT Portions of 18F-Fluoride PET/CT Bone Scans

Department of Nuclear Medicine, Yuan's General Hospital, 162 Cheng-Kung 1st Road, Kaohsiung 802, Taiwan

Received 13 June 2012; Accepted 24 August 2012

Academic Editors: A. Frenkel, P. Hartvig, and D. Morris

Copyright © 2012 Chao-Jung Chen and Shih-Ya Ma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Due to the frequently interrupted supply of 99mTc-methylene diphosphonate, the use of 18F-fluoride positron emission tomography (PET)/computed tomography (CT) has become more popular. The study aims to determine the percentage of extraosseous findings from the unenhanced CT portion of 18F-fluoride PET/CT scans. Materials and Methods. We retrospectively collected 18F-fluoride PET/CT studies between March 2010 and February 2011. The unenhanced CT portions of 18F-fluoride PET/CT were reviewed for each patient. Significant extraosseous findings related to malignancy from the unenhanced CT were recorded. Results. A total of 158 patients (110 females, 48 males) were included in the study. Clinically significant extraosseous findings from the unenhanced CT were found in 43 patients (27.2%). Previously unknown extraosseous findings were identified in 17 patients (10.8%) after a review of the 18F-fluoride PET/CT scan results. Most of the extraosseous findings were small pulmonary metastases or enlarged metastatic lymph nodes. Conclusion. It is not rare to identify new clinically significant extraosseous findings from the unenhanced CT of 18F-fluoride PET/CT studies. Therefore the clinical management of patients may be altered by the results, and a careful review of the unenhanced CT portion of 18F-fluoride PET/CT is mandatory.