Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Table 1

The levels of biochemical parameters of all groups.

Parameters	Control	ML	Mtx	Mtx + ML	ML + Mtx
MDA (nmol/g tissue)	937.5±71.03	872.3±120.3	1669.9±129.7^a	443.1±32.7^b,c	1500±80.9
GSH (nmol/g tissue)	1937±193.7	2116.3±189.1	2185.9±321.6	1847.0±111.1	1621±219.6
MPO (U/g protein)	58.3±7.9	70.07±11.7	201.9±15.5^a	80.7±10.7^b	154.9±29.8

^a𝑃<0.05, when compared to the control and ML groups.
^b𝑃<0.05, when compared to the Mtx group.
^c𝑃<0.05, when compared to the other groups.