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The Scientific World Journal
Volume 2013, Article ID 125027, 7 pages
http://dx.doi.org/10.1155/2013/125027
Research Article

Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content

1Laboratório de Glicoproteínas, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil
2Laboratório de Imunoparasitologia, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz/PE, Avenida Professor Moraes Rego s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil
3Laboratório de Produtos Naturais, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil

Received 31 May 2013; Accepted 29 June 2013

Academic Editors: F. A. Simmen and A. Surguchov

Copyright © 2013 Evellyne de Oliveira Figueirôa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An increasing number of biological activities presented by medicinal plants has been investigated over the years, and they are used in the search for new substances with lower side effects. Eugenia uniflora L. and Eugenia malaccensis L. (Myrtaceae) have many folk uses in various countries. This current study was designed to quantify the polyphenols and flavonoids contents and evaluate the immunomodulatory, antioxidant, and cytotoxic potentials of fractions from E. uniflora L. and E. malaccensis L. It was observed that the polyphenol content was higher in ethyl acetate fractions. These fractions have high antioxidant potential. E. malaccensis L. seeds showed the largest DPPH radical scavenger capacity (). The fractions of E. malaccensis L. leaves showed lower antioxidant capacity. The samples did not alter the profile of proinflammatory cytokines and nitric oxide release. The results indicate that species of the family Myrtaceae are rich in compounds with antioxidant capacity, which can help reduce the inflammatory response.