Development of Some Larval Nematodes in Experimental and Natural Animal Hosts: An Insight into Development of Pathological Lesions vis-a-vis Host-Parasite Interactions
Table 1
Experimental infection of laboratory animals with spiruroid nematodes.
Experimental animal
Infective dose (L3)
Mode of oral infection
Necropsy (DPI)
Results
Recovery percentage
Remarks
R1
75
Single dose
22
M = 5 (+YA 3) F = 17 (+YA 2)
36.0
Several worms (M or F) were under the 4th ecdysis
R2
121
Single dose
48
M = 24 (+YA 2) F = 24
41.5
R3
100
2 successive days ()
39
M = 16 (+YA 1) F = 19 (+YA 4)
40.0
R4
128
3 different days (Mx. = 55; Mi. = 21)
31
M = 17 (+YA 8) F = 28 (+YA 5)
45.3
Copious exudates in gastric mucosa, no lesion revealed
R5
546
10 different days (Mx. = 172; Mi. = 10)
41
Bunches of light pinkish worms (M + F) recovered
—
GP1
130
Single dose
108
—
—
—
GP2
50
3 different days (Mx. = 28; Mi. = 8)
41
M = 2 F = Nil
4.0
No lesion noted in the mucosa
R1
279
9 different days (Mx. = 80; Mi. = 6)
45
Two L3 recovered from multiple nodules on the gastric wall
—
Many nodular lesions showed cut sections of larvae. Several encapsulated larvae detected in the cut sections of gastric wall.
R2
87
10 different days (Mx. = 21; Mi. = 3)
48
One L3 recovered from the omentum close to ventral lobe of liver
—
R3
223
11 different days (Mx. = 72; Mi. = 50)
53
No larvae recovered
—
Several encapsulated larvae found in the cut sections of stomach wall.
R1
123
12 different days (Mx. = 52; Mi. = 1)
59
Encystment on the gastric wall; 4 nodular lesions on the intima 4–8 mm from the bulbous aorta.
R2
90
4 different days (Mx. = 54; Mi. = 7)
37 (died on the previous night)
14 YA recovered from the intima; may cut in the lesioned patches in stomach wall (L3) or aorta (L4)
—
Internal haemorrhage detected on postmortem suspected either from rupture of minute vessels or wall of aorta.
R: rabbit; GP: guinea pig; DPI: days postinfection; M: male, F: female, A: adult; YA: young adult; L3/L4: third-or fourth-stage larvae, Mx: maximum; Mi: minimum; —: not counted/no recovery.
