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The Scientific World Journal
Volume 2013, Article ID 163418, 8 pages
http://dx.doi.org/10.1155/2013/163418
Research Article

Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil

1Postgraduate Studies Program in Cardiology, School of Medicine, Clinical Research Center, No. 5 Andar, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil
2Postgraduate Studies Program in Epidemiology, School of Medicine, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
3National Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, 90035-903 Porto Alegre, RS, Brazil
4Department of Clinical Medicine, Universidade de Pernambuco, 50670-901 Recife, PE, Brazil
5Department of Tropical Medicine, Universidade Federal de Pernambuco, 50610-110 Recife, PE, Brazil
6Research Center Aggeu Magalhães, Fundação Oswaldo Cruz, 50.670-420 Recife, PE, Brazil
7Institute of Biological Sciences, Universidade de Pernambuco, 50670-901 Recife, PE, Brazil
8Institute of Tropical Pathology and Public Health, Universidade Federal de Goiás, 74605050 Goiania, GO, Brazil

Received 3 August 2013; Accepted 3 September 2013

Academic Editors: A. Mosavi-Jarrahi, E. A. Okiro, and E. Paci

Copyright © 2013 Sandra C. Fuchs et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiovascular disease has emerged as a crescent problem among HIV-infected population. This study aimed to determine the 10-year risk of coronary heart disease using the Framingham risk score among HIV-infected patients from three regions of Brazil. This is a pooled analysis of three cohort studies, which enrolled 3,829 individuals, 59% were men, 66% had white skin color, and mean age 39.0 ± 9.9 years. Comparisons among regions showed that there were marked differences in demographic, socioeconomic, clinical, and HIV-related characteristics. Prevalence of Framingham score ≥10 was 4.5% in the Southern, 4.2% in the Midwest, and 3.9% in the Northeast of Brazil. The Framingham score ≥10 was similar between regions for males, patients aged ≥60 years, with obesity, central obesity, hypertension, and diabetes mellitus. Women were three times more likely to have coronary heart disease in 10 years than men. Hypertension and diabetes increased more than four times the risk of coronary heart disease, followed by central obesity, obesity, and prehypertension. The use of antiretroviral agents and time since HIV diagnosis were not risk factors for coronary artery disease in 10 years. In conclusion, hypertension and diabetes are the strongest independent predictors of 10-year risk of coronary heart disease among HIV-infected population.