Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013 (2013), Article ID 176741, 6 pages
http://dx.doi.org/10.1155/2013/176741
Research Article

Association of FAS and FAS Ligand Genes Polymorphism and Risk of Systemic Lupus Erythematosus

1Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
2Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
3Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
4Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran

Received 25 August 2013; Accepted 17 September 2013

Academic Editors: A. La Cava and M. Pinti

Copyright © 2013 Bita Moudi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility. Materials and Methods. In this case-control study, 106 SLE patients and 149 sex, age, and ethnicity matched healthy controls were genotyped for the Fas A-670G and FasLC-844T polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results. The frequency of -670AA genotype was significantly higher in SLE patients than control group and the risk of SLE was 2.1-fold greater in subjects with AA genotype ( ). The frequency of -670A allele was significantly higher in SLE patients than in controls too (58% versus 49%, ). The -844CC genotype frequency was significantly higher in SLE patients than in healthy controls and the risk of SLE was 2.8-fold greater in these subjects ( ). The C allele frequency was significantly higher in patients than in controls (69% versus 49%, ). Increased SLE risk was observed in individuals with combined effect of Fas-670AA and FasL-844CC genotypes ( ). Conclusion. Fas-670AA and FasL-844CC genotypes were associated with SLE risk, and combined effect of -670AA and -844CC genotypes might increase SLE susceptibility.