Structure-Activity Relationships of 3,3′-Phenylmethylene-bis-4-hydroxycoumarins: Selective and Potent Inhibitors of Gram-Positive Bacteria

Figure 2

Multiple sequence alignment of azoreductase from Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella sp. Amino acid residues are colored to indicate their similarity: blue=hydrophobic, red=acidic, and green=basic residues. For comparative model, the sequence identity with the template is of 34%.