Structure-Activity Relationships of 3,3′-Phenylmethylene-bis-4-hydroxycoumarins: Selective and Potent Inhibitors of Gram-Positive Bacteria

Table 3

Statistical results of CoMFA and CoMSIA models.

Models	Descriptors	Statistical parameters
		𝑞^2	𝑟^2	N	SEE	F	Field contribution (%)
CoMFA	S/E	0.694	0.894	2	0.929	46.3	59.2/40.8
CoMSIA	S/E/H/D/A	0.683	0.977	4	0.479	94.8	10.3/25.6/19.9/31.7/9.5

S: steric field; E: electrostatic field; H: hydrophobic field; D: donor; A: acceptor; 𝑞²: cross-validated correlation coefficient; 𝑟²: non-cross-validated correlation coefficient; N: optimal number of components; SEE: standard error of estimate; F: F test.