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The Scientific World Journal
Volume 2013 (2013), Article ID 186537, 8 pages
Research Article

Alkyne-Azide Cycloaddition Catalyzed by Silver Chloride and “Abnormal” Silver N-Heterocyclic Carbene Complex

1Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, 50200 Toluca, MEX, Mexico
2Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario Cerro de las Campanas s/n, 76010 Querétaro, QRO, Mexico

Received 12 August 2013; Accepted 11 September 2013

Academic Editors: A. Brandi, A. Marra, O. Navarro, D. Savoia, and G. C. Vougioukalakis

Copyright © 2013 Aldo I. Ortega-Arizmendi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A library of 1,2,3-triazoles was synthesized from diverse alkynes and azides using catalytic amounts of silver chloride instead of copper compounds. In addition, a novel “abnormal” silver N-heterocyclic carbene complex was tested as catalyst in this process. The results suggest that the reaction requires only 0.5% of silver complex, affording 1,2,3-triazoles in good yields.