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The Scientific World Journal
Volume 2013, Article ID 189149, 11 pages
http://dx.doi.org/10.1155/2013/189149
Review Article

Exercise-Induced Muscle Damage and Running Economy in Humans

Human Performance Laboratory, UNESP, Avenue 24 A, Bela Vista-Rio, 13506-900 Rio Claro, SP, Brazil

Received 18 December 2012; Accepted 18 January 2013

Academic Editors: L. Guimarães-Ferreira, H. Nicastro, J. Wilson, and N. E. Zanchi

Copyright © 2013 Cláudio de Oliveira Assumpção et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Daniels and N. Daniels, “Running economy of elite male and elite female runners,” Medicine and Science in Sports and Exercise, vol. 24, no. 4, pp. 483–489, 1992. View at Google Scholar · View at Scopus
  2. T. Anderson, “Biomechanics and running economy,” Sports Medicine, vol. 22, no. 2, pp. 76–89, 1996. View at Google Scholar · View at Scopus
  3. P. U. Saunders, D. B. Pyne, R. D. Telford, and J. A. Hawley, “Factors affecting running economy in trained distance runners,” Sports Medicine, vol. 34, no. 7, pp. 465–485, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. A. M. Turner, M. Owings, and J. A. Schwane, “Improvement in running economy after 6 weeks of plyometric training,” Journal of Strength and Conditioning Research, vol. 17, no. 1, pp. 60–67, 2003. View at Google Scholar
  5. L. G. A. Guglielmo, C. C. Greco, and B. S. Denadai, “Effects of strength training on running economy,” International Journal of Sports Medicine, vol. 30, no. 1, pp. 27–32, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. P. U. Saunders, R. D. Telford, D. B. Pyne, A. G. Hahn, and C. J. Gore, “Improved running economy and increased hemoglobin mass in elite runners after extended moderate altitude exposure,” Journal of Science and Medicine in Sport, vol. 12, no. 1, pp. 67–72, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. D. Carmichael, J. M. Davis, E. A. Murphy et al., “Recovery of running performance following muscle-damaging exercise: relationship to brain IL-1β,” Brain, Behavior, and Immunity, vol. 19, no. 5, pp. 445–452, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. M. D. Carmichael, J. M. Davis, E. A. Murphy et al., “Role of brain IL-1β on fatigue after exercise-induced muscle damage,” American Journal of Physiology, vol. 291, no. 5, pp. R1344–R1348, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Marcora and A. Bosio, “Effect of exercise-induced muscle damage on endurance running performance in humans,” Scandinavian Journal of Medicine and Science in Sports, vol. 17, no. 6, pp. 662–671, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Paschalis, Y. Koutedakis, V. Baltzopoulos, V. Mougios, A. Z. Jamurtas, and V. Theoharis, “The effects of muscle damage on running economy in healthy males,” International Journal of Sports Medicine, vol. 26, no. 10, pp. 827–831, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. T. C. Chen, K. Nosaka, M. J. Lin, H. L. Chen, and C. J. Wu, “Changes in running economy at different intensities following downhill running,” Journal of Sports Sciences, vol. 27, no. 11, pp. 1137–1144, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Burt, K. Lamb, C. Nicholas, and C. Twist, “Effects of repeated bouts of squatting exercise on sub-maximal endurance running performance,” European Journal of Applied Physiology, vol. 113, no. 2, pp. 285–293, 2013. View at Google Scholar
  13. A. M. Jones and H. Carter, “The effect of endurance training on parameters of aerobic fitness,” Sports Medicine, vol. 29, no. 6, pp. 373–386, 2000. View at Google Scholar · View at Scopus
  14. P. A. Farrell, J. H. Wilmore, and E. F. Coyle, “Plasma lactate accumulation and distance running performance,” Medicine and Science in Sports and Exercise, vol. 11, no. 4, pp. 338–344, 1979. View at Google Scholar · View at Scopus
  15. R. R. Pate, C. A. Macera, S. P. Bailey, W. P. Bartoli, and K. E. Powell, “Physiological, anthropometric, and training correlates of running economy,” Medicine and Science in Sports and Exercise, vol. 24, no. 10, pp. 1128–1133, 1992. View at Google Scholar · View at Scopus
  16. D. W. Morgan and J. T. Daniels, “Relationship between VO2max and the aerobic demand of running in elite distance runners,” International Journal of Sports Medicine, vol. 15, no. 7, pp. 426–429, 1994. View at Google Scholar
  17. E. F. Coyle, A. R. Coggan, M. K. Hopper, and T. J. Walters, “Determinants of endurance in well-trained cyclists,” Journal of Applied Physiology, vol. 64, no. 6, pp. 2622–2630, 1988. View at Google Scholar · View at Scopus
  18. D. L. Costill, H. Thomason, and E. Roberts, “Fractional utilization of the aerobic capacity during distance running,” Medicine and Science in Sports and Exercise, vol. 5, no. 4, pp. 248–252, 1973. View at Google Scholar · View at Scopus
  19. D. L. Conley and G. S. Krahenbuhl, “Running economy and distance running performance of highly trained athletes,” Medicine and Science in Sports and Exercise, vol. 12, no. 5, pp. 357–360, 1980. View at Google Scholar · View at Scopus
  20. D. W. Morgan, P. E. Martin, G. S. Krahenbuhl, and F. D. Baldini, “Variability in running economy and mechanics among trained male runners,” Medicine and Science in Sports and Exercise, vol. 23, no. 3, pp. 378–383, 1991. View at Google Scholar · View at Scopus
  21. W. A. Sparrow and K. M. Newell, “Metabolic energy expenditure and the regulation of movement economy,” Psychonomic Bulletin and Review, vol. 5, no. 2, pp. 173–196, 1998. View at Google Scholar · View at Scopus
  22. D. W. Morgan, P. E. Martin, and G. S. Krahenbuhl, “Factors affecting running economy,” Sports Medicine, vol. 7, no. 5, pp. 310–330, 1989. View at Google Scholar · View at Scopus
  23. L. W. Armstrong and C. M. Maresh, “The induction and decay of heat acclimatisation in trained athletes,” Sports Medicine, vol. 12, no. 5, pp. 302–312, 1991. View at Google Scholar · View at Scopus
  24. P. U. Saunders, R. D. Telford, D. B. Pyne et al., “Short-term plyometric training improves running economy in highly trained middle and long distance runners,” Journal of Strength and Conditioning Research, vol. 20, no. 4, pp. 947–954, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. Ø. Støren, J. Helgerud, E. M. Støa, and J. Hoff, “Maximal strength training improves running economy in distance runners,” Medicine and Science in Sports and Exercise, vol. 40, no. 6, pp. 1087–1092, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. L. J. Brandon, “Physiological factors associated with middle distance running performance,” Sports Medicine, vol. 19, no. 4, pp. 268–277, 1995. View at Google Scholar · View at Scopus
  27. B. S. Denadai, M. J. Ortiz, C. C. Greco, and M. T. De Mello, “Interval training at 95% and 100% of the velocity at VO2 max: effects on aerobic physiological indexes and running performance,” Applied Physiology, Nutrition and Metabolism, vol. 31, no. 6, pp. 737–743, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Bosco, G. Montanari, R. Ribacchi et al., “Relationship between the efficiency of muscular work during jumping and the energetics of running,” European Journal of Applied Physiology and Occupational Physiology, vol. 56, no. 2, pp. 138–143, 1987. View at Google Scholar · View at Scopus
  29. J. R. Fletcher, S. P. Esau, and B. R. MacIntosh, “Changes in tendon stiffness and running economy in highly trained distance runners,” European Journal of Applied Physiology, vol. 110, no. 5, pp. 1037–1046, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Arampatzis, G. De Monte, K. Karamanidis, G. Morey-Klapsing, S. Stafilidis, and G. P. Brüggemann, “Influence of the muscle-tendon unit's mechanical and morphological properties on running economy,” The Journal of Experimental Biology, vol. 209, no. 17, pp. 3345–3357, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. R. W. Spurrs, A. J. Murphy, and M. L. Watsford, “The effect of plyometric training on distance running performance,” European Journal of Applied Physiology, vol. 89, no. 1, pp. 1–7, 2003. View at Google Scholar · View at Scopus
  32. B. D. Levine and J. Stray-Gundersen, “'Living high-training low: effect of moderate-altitude acclimatization with low-altitude training on performance,” Journal of Applied Physiology, vol. 83, no. 1, pp. 102–112, 1997. View at Google Scholar · View at Scopus
  33. E. Y. Robertson, P. U. Saunders, D. B. Pyne, C. J. Gore, and J. M. Anson, “Effectiveness of intermittent training in hypoxia combined with live high/train low,” European Journal of Applied Physiology, vol. 110, no. 2, pp. 379–387, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. J. P. Wehrlin, P. Zuest, J. Hallén, and B. Marti, “Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes,” Journal of Applied Physiology, vol. 100, no. 6, pp. 1938–1945, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Svedenhag, “Running economy,” in Running and Science, J. Bangsbo and H. Larsen, Eds., pp. 85–105, Munksgaard, Copenhagen, Denmark, 2000. View at Google Scholar
  36. J. A. Houmard, D. L. Costill, J. A. Davis, J. B. Mitchell, D. D. Pascoe, and R. A. Robergs, “The influence of exercise intensity on heat acclimation in trained subjects,” Medicine and Science in Sports and Exercise, vol. 22, no. 5, pp. 615–620, 1990. View at Google Scholar · View at Scopus
  37. C. Byrne, C. Twist, and R. Eston, “Neuromuscular function after exercise-induced muscle damage theoretical and applied implications,” Sports Medicine, vol. 34, no. 1, pp. 49–69, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. J. C. Tee, A. N. Bosch, and M. I. Lambert, “Metabolic consequences of exercise-induced muscle damage,” Sports Medicine, vol. 37, no. 10, pp. 827–836, 2007. View at Google Scholar · View at Scopus
  39. G. L. Warren, D. A. Lowe, and R. B. Armstrong, “Measurement tools used in the study of eccentric contraction-induced injury,” Sports Medicine, vol. 27, no. 1, pp. 43–59, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Friden, M. Sjostrom, and B. Ekblom, “Myofibrillar damage following intense eccentric exercise in man,” International Journal of Sports Medicine, vol. 4, no. 3, pp. 170–176, 1983. View at Google Scholar · View at Scopus
  41. M. J. Gibala, J. D. MacDougall, M. A. Tarnopolsky, W. T. Stauber, and A. Elorriaga, “Changes in human skeletal muscle ultrastructure and force production after acute resistance exercise,” Journal of Applied Physiology, vol. 78, no. 2, pp. 702–708, 1995. View at Google Scholar · View at Scopus
  42. T. Hortobágyi, J. Houmard, D. Fraser, R. Dudek, J. Lambert, and J. Tracy, “Normal forces and myofibrillar disruption after repeated eccentric exercise,” Journal of Applied Physiology, vol. 84, no. 2, pp. 492–498, 1998. View at Google Scholar · View at Scopus
  43. C. Byrne, R. G. Eston, and R. H. T. Edwards, “Characteristics of isometric and dynamic strength loss following eccentric exercise-induced muscle damage,” Scandinavian Journal of Medicine and Science in Sports, vol. 11, no. 3, pp. 134–140, 2001. View at Google Scholar · View at Scopus
  44. W. T. Stauber, P. M. Clarkson, V. K. Fritz, and W. J. Evans, “Extracellular matrix disruption and pain after eccentric muscle action,” Journal of Applied Physiology, vol. 69, no. 3, pp. 868–874, 1990. View at Google Scholar · View at Scopus
  45. J. Fridén and R. L. Lieber, “Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components,” Acta Physiologica Scandinavica, vol. 171, no. 3, pp. 321–326, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. J. B. Rodenburg, P. R. Bar, and R. W. De Boer, “Relations between muscle soreness and biochemical and functional outcomes of eccentric exercise,” Journal of Applied Physiology, vol. 74, no. 6, pp. 2976–2983, 1993. View at Google Scholar · View at Scopus
  47. D. B. Pyne, “Exercise-induced muscle damage and inflammation: a review,” Australian Journal of Science and Medicine in Sport, vol. 26, no. 3-4, pp. 49–58, 1994. View at Google Scholar · View at Scopus
  48. T. C. Chen, H. L. Chen, A. J. Pearce, and K. Nosaka, “Attenuation of eccentric exercise-induced muscle damage by preconditioning exercises,” Medicine and Science in Sports and Exercise, vol. 44, no. 11, pp. 2090–2098, 2012. View at Google Scholar
  49. P. V. Komi and J. T. Viitasalo, “Changes in motor unit activity and metabolism in human skeletal muscle during and after repeated eccentric and concentric contractions,” Acta Physiologica Scandinavica, vol. 100, no. 2, pp. 246–254, 1977. View at Google Scholar · View at Scopus
  50. P. M. Clarkson, W. C. Byrnes, K. M. McCormick, L. P. Turcotte, and J. S. White, “Muscle soreness and serum creatine kinase activity following isometric, eccentric, and concentric exercise,” International Journal of Sports Medicine, vol. 7, no. 3, pp. 152–155, 1986. View at Google Scholar · View at Scopus
  51. K. Vissing, K. Overgaard, A. Nedergaard, A. Fredsted, and P. Schjerling, “Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle,” European Journal of Applied Physiology, vol. 103, no. 3, pp. 323–332, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. D. M. DiPasquale, R. J. Bloch, and R. M. Lovering, “Determinants of the repeated-bout effect after lengthening contractions,” American Journal of Physical and Medicine Rehabilitation, vol. 90, no. 10, pp. 816–824, 2011. View at Google Scholar
  53. G. Y. Millet and R. Lepers, “Alterations of neuromuscular function after prolonged running, cycling and skiing exercises,” Sports Medicine, vol. 34, no. 2, pp. 105–116, 2004. View at Publisher · View at Google Scholar · View at Scopus
  54. R. M. Enoka, “Eccentric contractions require unique activation strategies by the nervous system,” Journal of Applied Physiology, vol. 81, no. 6, pp. 2339–2346, 1996. View at Google Scholar · View at Scopus
  55. S. H. Westing, A. G. Cresswell, and A. Thorstensson, “Muscle activation during maximal voluntary eccentric and concentric knee extension,” European Journal of Applied Physiology and Occupational Physiology, vol. 62, no. 2, pp. 104–108, 1991. View at Publisher · View at Google Scholar · View at Scopus
  56. E. Kellis and V. Baltzopoulos, “Muscle activation differences between eccentric and concentric isokinetic exercise,” Medicine and Science in Sports and Exercise, vol. 30, no. 11, pp. 1616–1623, 1998. View at Google Scholar · View at Scopus
  57. R. M. Enoka, Neuromechanics of Human Movementedition, Human Kinetics Books, Champaign, Ill, USA, 3rd edition, 2002.
  58. D. A. Jones, D. J. Newham, and C. Torgan, “Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain,” The Journal of Physiology, vol. 412, pp. 415–427, 1989. View at Google Scholar · View at Scopus
  59. U. Proske and D. L. Morgan, “Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications,” The Journal of Physiology, vol. 537, no. 2, pp. 333–345, 2001. View at Publisher · View at Google Scholar · View at Scopus
  60. D. G. Allen and H. Westerblad, “Role of phosphate and calcium stores in muscle fatigue,” The Journal of Physiology, vol. 536, no. 3, pp. 657–665, 2001. View at Publisher · View at Google Scholar · View at Scopus
  61. R. Child, S. Brown, S. Day, A. Donnelly, H. Roper, and J. Saxton, “Changes in indices of antioxidant status, lipid peroxidation and inflammation in human skeletal muscle after eccentric muscle actions,” Clinical Science, vol. 96, no. 1, pp. 105–115, 1999. View at Publisher · View at Google Scholar · View at Scopus
  62. K. Nosaka and P. M. Clarkson, “Muscle damage following repeated bouts of high force eccentric exercise,” Medicine and Science in Sports and Exercise, vol. 27, no. 9, pp. 1263–1269, 1995. View at Google Scholar · View at Scopus
  63. M. P. McHugh, “Recent advances in the understanding of the repeated bout effect: the protective effect against muscle damage from a single bout of eccentric exercise,” Scandinavian Journal of Medicine and Science in Sports, vol. 13, no. 2, pp. 88–97, 2003. View at Publisher · View at Google Scholar · View at Scopus
  64. M. P. McHugh, D. A. J. Connolly, R. G. Eston, and G. W. Gleim, “Exercise-induced muscle damage and potential mechanisms for the repeated bout effect,” Sports Medicine, vol. 27, no. 3, pp. 157–170, 1999. View at Publisher · View at Google Scholar · View at Scopus
  65. K. Nosaka and K. Sakamoto, “Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors,” Medicine and Science in Sports and Exercise, vol. 33, no. 1, pp. 22–29, 2001. View at Google Scholar · View at Scopus
  66. T. C. Chen, K. Nosaka, and P. Sacco, “Intensity of eccentric exercise, shift of optimum angle, and the magnitude of repeated-bout effect,” Journal of Applied Physiology, vol. 102, no. 3, pp. 992–999, 2007. View at Publisher · View at Google Scholar · View at Scopus
  67. M. J. Newton, G. T. Morgan, P. Sacco, D. W. Chapman, and K. Nosaka, “Comparison of responses to strenuous eccentric exercise of the elbow flexors between resistance-trained and untrained men,” Journal of Strength and Conditioning Research, vol. 22, no. 2, pp. 597–607, 2008. View at Google Scholar · View at Scopus
  68. T. C. Chen, H. L. Chen, M. J. Lin, C. J. Wu, and K. Nosaka, “Potent protective effect conferred by four bouts of low-intensity eccentric exercise,” Medicine and Science in Sports and Exercise, vol. 42, no. 5, pp. 1004–1012, 2010. View at Publisher · View at Google Scholar · View at Scopus
  69. G. Howatson, K. Van Someren, and T. Hortobágyi, “Repeated bout effect after maximal eccentric exercise,” International Journal of Sports Medicine, vol. 28, no. 7, pp. 557–563, 2007. View at Publisher · View at Google Scholar · View at Scopus
  70. T. C. Chen and K. Nosaka, “Responses of elbow flexors to two strenuous eccentric exercise bouts separated by three days,” Journal of Strength and Conditioning Research, vol. 20, no. 1, pp. 108–116, 2006. View at Publisher · View at Google Scholar · View at Scopus
  71. G. L. Warren, K. M. Hermann, C. P. Ingalls, M. R. Masselli, and R. B. Armstrong, “Decreased EMG median frequency during a second bout of eccentric contractions,” Medicine and Science in Sports and Exercise, vol. 32, no. 4, pp. 820–829, 2000. View at Google Scholar · View at Scopus
  72. G. Howatson and K. A. Van Someren, “Ice massage: effects on exercise-induced muscle damage,” Journal of Sports Medicine and Physical Fitness, vol. 43, no. 4, pp. 500–505, 2003. View at Google Scholar · View at Scopus
  73. K. Nosaka, M. Newton, P. Sacco, D. Chapman, and A. Lavender, “Partial protection against muscle damage by eccentric actions at short muscle lengths,” Medicine and Science in Sports and Exercise, vol. 37, no. 5, pp. 746–753, 2005. View at Publisher · View at Google Scholar · View at Scopus
  74. D. J. Newham, D. A. Jones, and P. M. Clarkson, “Repeated high-force eccentric exercise: effects on muscle pain and damage,” Journal of Applied Physiology, vol. 63, no. 4, pp. 1381–1386, 1987. View at Google Scholar · View at Scopus
  75. H. S. Thompson, P. M. Clarkson, and S. P. Scordilis, “The repeated bout effect and heat shock proteins: intramuscular HSP27 and HSP70 expression following two bouts of eccentric exercise in humans,” Acta Physiologica Scandinavica, vol. 174, no. 1, pp. 47–56, 2002. View at Publisher · View at Google Scholar · View at Scopus
  76. T. M. Lehti, R. Kalliokoski, and J. Komulainen, “Repeated bout effect on the cytoskeletal proteins titin, desmin, and dystrophin in rat skeletal muscle,” Journal of Muscle Research and Cell Motility, vol. 28, no. 1, pp. 39–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
  77. R. B. Child, J. M. Saxton, and A. E. Donnelly, “Comparison of eccentric knee extensor muscle actions at two muscle lengths on indices of damage and angle-specific force production in humans,” Journal of Sports Sciences, vol. 16, no. 4, pp. 301–308, 1998. View at Google Scholar · View at Scopus
  78. S. V. Brooks and J. A. Faulkner, “Severity of contraction-induced injury is affected by velocity only during stretches of large strain,” Journal of Applied Physiology, vol. 91, no. 2, pp. 661–666, 2001. View at Google Scholar · View at Scopus
  79. M. J. Falvo, B. K. Schilling, R. J. Bloomer, and W. A. Smith, “Repeated bout effect is absent in resistance trained men: an electromyographic analysis,” Journal of Electromyography and Kinesiology, vol. 19, no. 6, pp. e529–e535, 2009. View at Publisher · View at Google Scholar · View at Scopus
  80. K. Nosaka, K. Sakamoto, M. Newton, and P. Sacco, “How long does the protective effect on eccentric exercise-induced muscle damage last?” Medicine and Science in Sports and Exercise, vol. 33, no. 9, pp. 1490–1495, 2001. View at Google Scholar · View at Scopus
  81. P. M. Clarkson, K. Nosaka, and B. Braun, “Muscle function after exercise-induced muscle damage and rapid adaptation,” Medicine and Science in Sports and Exercise, vol. 24, no. 5, pp. 512–520, 1992. View at Google Scholar · View at Scopus
  82. R. G. Eston, S. Finney, S. Baker, and V. Baltzopoulos, “Muscle tenderness and peak torque changes after downhill running following a prior bout of isokinetic eccentric exercise,” Journal of Sports Sciences, vol. 14, no. 4, pp. 291–299, 1996. View at Publisher · View at Google Scholar · View at Scopus
  83. D. L. Macintyre, W. D. Reid, D. M. Lyster, I. J. Szasz, and D. C. Mckenzie, “Presence of WBC, decreased strength, and delayed soreness in muscle after eccentric exercise,” Journal of Applied Physiology, vol. 80, no. 3, pp. 1006–1013, 1996. View at Google Scholar · View at Scopus
  84. R. Molina and B. S. Denadai, “Dissociated time course recovery between rate of force development and peak torque after eccentric exercise,” Clinical Physiology and Functional Imaging, vol. 32, no. 3, pp. 179–184, 2012. View at Google Scholar
  85. L. C. R. Lima and B. S. Denadai, “The repeated bout effect: a comparison between upper and lower limbs,” Motriz, vol. 17, no. 4, pp. 738–747, 2011. View at Google Scholar
  86. R. Molina and B. S. Denadai, “Muscle damage slows oxygen uptake kinetics during moderate-intensity exercise performed ate high pedal rate,” Applied Physiology Nutrition and Metabolism, vol. 36, no. 6, pp. 848–855, 2011. View at Google Scholar
  87. P. Vassilis, B. Vassilios, M. Vassilis et al., “Isokinetic eccentric exercise of quadriceps femoris does not affect running economy,” Journal of Strength and Conditioning Research, vol. 22, no. 4, pp. 1222–1227, 2008. View at Google Scholar · View at Scopus
  88. K. E. Scott, R. Rozenek, A. C. Russo, J. A. Crussemeyer, and M. G. Lacourse, “Effects of delayed onset muscle soreness on selected physiological responses to submaximal running,” Journal of Strength and Conditioning Research, vol. 17, no. 4, pp. 652–658, 2003. View at Google Scholar
  89. H. Kyrolainen, T. Pullinen, R. Candau, J. Avela, P. Huttunen, and P. V. Komi, “Effects of marathon running on running economy and kinematics,” European Journal of Applied Physiology, vol. 82, no. 4, pp. 297–304, 2000. View at Publisher · View at Google Scholar · View at Scopus
  90. G. A. Gaesser and D. C. Poole, “The slow component of oxygen uptake kinetics in humans,” Exercise and Sport Sciences Reviews, vol. 24, pp. 35–71, 1996. View at Google Scholar · View at Scopus
  91. D. T. Cannon, A. C. White, M. F. Andriano, F. W. Kolkhorst, and H. B. Rossiter, “Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans,” The Journal of Physiology, vol. 589, no. 3, pp. 727–739, 2011. View at Publisher · View at Google Scholar · View at Scopus
  92. J. Hamill, P. S. Freedson, P. M. Clarkson, and B. Braun, “Muscle soreness during running: biomechanical and physiological considerations,” Journal of Applied Biomechanics, vol. 7, no. 2, pp. 125–137, 1991. View at Google Scholar
  93. W. A. Braun and D. J. Dutto, “The effects of a single bout of downhill running and ensuing delayed onset of muscle soreness on running economy performed 48 h later,” European Journal of Applied Physiology, vol. 90, no. 1-2, pp. 29–34, 2003. View at Publisher · View at Google Scholar · View at Scopus
  94. T. C. Chen, K. Nosaka, and J. H. Tu, “Changes in running economy following downhill running,” Journal of Sports Sciences, vol. 25, no. 1, pp. 55–63, 2007. View at Publisher · View at Google Scholar · View at Scopus
  95. R. G. Eston, J. Mickleborough, and V. Baltzopoulos, “Eccentric activation and muscle damage: biomechanical and physiological considerations during downhill running,” British Journal of Sports Medicine, vol. 29, no. 2, pp. 89–94, 1995. View at Google Scholar · View at Scopus
  96. H. J. Appell, J. M. C. Soares, and J. A. R. Duarte, “Exercise, muscle damage and fatigue,” Sports Medicine, vol. 13, no. 2, pp. 108–115, 1992. View at Google Scholar · View at Scopus
  97. G. Y. Millet, K. Tomazin, S. Verges et al., “Neuromuscular consequences of an extreme mountain ultra-marathon,” PLoS ONE, vol. 6, no. 2, Article ID e17059, 2011. View at Publisher · View at Google Scholar · View at Scopus
  98. T. C. Chen, K. Nosaka, and C. C. Wu, “Effects of a 30-min running performed daily after downhill running on recovery of muscle function and running economy,” Journal of Science and Medicine in Sport, vol. 11, no. 3, pp. 271–279, 2008. View at Publisher · View at Google Scholar · View at Scopus
  99. S. A. Hahn, L. F. Ferreira, J. B. Williams et al., “Downhill treadmill running trains the rat spinotrapezius muscle,” Journal of Applied Physiology, vol. 102, no. 1, pp. 412–416, 2007. View at Publisher · View at Google Scholar · View at Scopus
  100. B. C. Pereira, L. A. Filho, G. F. Alves et al., “A new overtraining protocol for mice based on downhill running sessions,” Clinical and Experimental Pharmacology and Physiology, vol. 39, no. 9, pp. 793–798, 2012. View at Google Scholar
  101. R. Lynn and D. L. Morgan, “Decline running produces more sarcomeres in rat vastus intermedius muscle fibers than does incline running,” Journal of Applied Physiology, vol. 77, no. 3, pp. 1439–1444, 1994. View at Google Scholar · View at Scopus
  102. B. Essen, “Glycogen depletion of different fibre types in human skeletal muscle during intermittent and continuous exercise,” Acta Physiologica Scandinavica, vol. 103, no. 4, pp. 446–455, 1978. View at Google Scholar · View at Scopus
  103. D. A. Jones, D. J. Newham, J. M. Round, and S. E. J. Tolfree, “Experimental human muscle damage: morphological changes in relation to other indices of damage,” The Journal of Physiology, vol. 375, pp. 435–448, 1986. View at Google Scholar · View at Scopus
  104. T. C. Chen, “Effects of a second bout of maximal eccentric exercise on muscle damage and electromyographic activity,” European Journal of Applied Physiology, vol. 89, no. 2, pp. 115–121, 2003. View at Google Scholar · View at Scopus
  105. W. C. Byrnes, P. M. Clarkson, J. S. White et al., “Delayed onset muscle soreness following repeated bouts of downhill running,” Journal of Applied Physiology, vol. 59, no. 3, pp. 710–715, 1985. View at Google Scholar · View at Scopus
  106. T. C. Chen, H. L. Chen, C. J. Wu et al., “Changes in running economy following a repeated bout of downhill running,” Journal of Exercise Science and Fitness, vol. 5, no. 2, pp. 109–117, 2007. View at Google Scholar · View at Scopus
  107. G. Howatson, M. P. McHugh, J. A. Hill et al., “Influence of tart cherry juice on indices of recovery following marathon running,” Scandinavian Journal of Medicine and Science in Sports, vol. 20, no. 6, pp. 843–852, 2010. View at Publisher · View at Google Scholar · View at Scopus
  108. K. S. Kuehl, E. T. Perrier, D. L. Elliot, and J. C. Chesnutt, “Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial,” Journal of the International Society of Sports Nutrition, vol. 7, article 17, 2010. View at Publisher · View at Google Scholar · View at Scopus