Online Monitoring Oxidative Products and Metabolites of Nicotine by Free Radicals Generation with Fenton Reaction in Tandem Mass Spectrometry

Table 1

Metabolic derivatives of nicotine in EEO/ESI-MS/MS. The molecular formula, molecular weight, and 𝑚/𝑧 of parent ion and daughter ions are listed.

Name	Molecular formula	Molecular weight (Da)	Parent ion	Daughter ions
Nicotine	C10H14N2	162.12	162.2	117, 130, 132
Cotinine	C10H12N2O	176.22	177.7	80, 119.5, 134.5
trans-3′-Hydroxyl cotinine	C10H12N2O2	192.21	194.0	106, 118, 134
Nornicotine	C9H12N2	148.20	148.7	80, 130
Nicotine-N-oxide	C10H14N2O	178.23	179.0	120, 130, 148
Norcotinine	C9H10N2O	162.19	162.5	67, 93, 119
4-Oxo-4-(3-pyridyl)-butanoic acid	C9H9NO3	179.17	180.2	81, 99.5, 108.6
4-Hydroxy-4-(3-pyridyl)-butanoic acid	C9H11NO3	181.07	182.2	84, 91, 122, 136
Cotinine-N′-oxide	C10H12N2O2	192.21	192.9	80, 121